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Paget's Disease of Bone

Clinical Assessment, Present and Future Therapy Proceedings of the Symposium on the Treatment of Paget's Disease of Bone, Held October 20, 1989 in New York City

Frederick Singer (Herausgeber)

Buch | Hardcover

335 Seiten

1977 | 1991 ed.
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-30996-0 (ISBN)

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Paget's disease is an old disease historically, but a new disease therapeutic- ally. Human remains unearthed in Lancashire, England, dating from ap- proximately 900 AD, show clear evidence of the aftliction. However, it was not until the 1800s that physicians rediscovered the condition, and a little more than 100 years ago that Sir James Paget published a perceptive and accurate description of the disease from the clinical and pathologic points of view. He felt the disease represented an inflammatory condition of the skeleton and hence named it osteitis deformans. The condition again lapsed into anonymity for several decades afterwards, and therapeutic approaches did not evolve until after World War II when several groups, located mainly in the Boston area, began using a variety of agents, includ- ing corticosteroids for treatment of this condition. These early attempts at therapy were unsuccessful and the condition remained essentially untreat- able until the development of the calcitonins and the bisphosphonates in the 1970s.
In 1978, the Paget's Disease Foundation, a private nonprofit volun- tary health agency, was founded to assist individuals aftlicted by Paget's disease of bone, to provide education regarding this condition to the medical community, and to encourage research efforts to better under- stand and treat the condition. An international conference was organized under the aegis of the Paget's Disease Foundation and was held in New York City in October, 1989, ten years after the founding of the Paget's Disease Foundation.

1 The Radiology of Paget's Disease.- 2 The Biochemistry of Paget's Disease.- 3 The Pathology of Paget's Disease.- 4 Indications for Medical Treatment of Paget's Disease of Bone.- 5 Experiences with Porcine and Salmon Calcitonin in the Treatment of Paget's Disease.- 6 Experiences with Human Calcitonin in the Treatment of Paget's Disease of Bone.- 7 Resistance to Calcitonin.- 8 Treatment of Paget's Disease with Etidronate Disodium.- 9 Disodium Pamidronate Therapy of Paget's Disease.- 10 Treatment of Paget's Disease with the New Bisphosphonates.- 11 Alternative Modes of Administration of Salmon Calcitonin in Paget's Disease of Bone.- 12 Treatment of Paget's Disease with Short Courses of Bisphosphonates.- 13 Two Decades of Experiences in the Treatment of Paget's Disease of Bone with Plicamycin (Mithramycin).- 14 Arthritis and Paget's Disease of Bone.- 15 Surgery in Paget's Disease.- Annotated Bibliography.- Author Index.

Reihe/Serie	Topics in Bone & Mineral Disorders
Zusatzinfo	biography
Sprache	englisch
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Diabetologie
	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
ISBN-10	0-306-30996-3 / 0306309963
ISBN-13	978-0-306-30996-0 / 9780306309960
Zustand	Neuware