Calcium and the Secretory Process
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-30778-2 (ISBN)
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But since so much experimentation has been carried out on this and related topics during the last decade or two, I felt it was still necessary to visualize this venture from two alternative ap- proaches: (1) a more general one, which would cover the subject of calcium and the secretory process from a broad perspective, but of course not in great detail, and (2) a more specific one, restricting coverage to carefully defined limits but with comprehensive analysis of limited topics. The final course undertaken appears to lie somewhere between these two extremes.
1 General Concepts.- Biological Importance of Calcium.- Calcium Distribution and Tissue Concentrations.- Redistribution of Calcium during Stimulation.- Regulation of Cell Calcium.- Binding.- Exchange Diffusion.- Active Transport.- Calcium and Membrane Permeability.- Ion Antagonisms.- Summary and Conclusions.- 2 Action of Calcium on the Secretory Process.- Cholinergic Neurons, Chromaffin Cells, and Neurosecretory Cells.- Historical Background.- Electrophysiological Events Associated with Secretion.- Role of Monovalent Cations.- Multivalent Cations.- Conclusions.- Other Neuronal Systems.- Excitatory and Inhibitory Synapses.- Adrenergic Synapses.- Release of Other Biogenic Amines.- Histamine.- 5-Hydroxytryptamine.- Release of Water and Protein.- Salivary Gland.- Exocrine Pancreas.- Granular Proteins from Leukocytes.- Gastric Secretion.- Endocrine Secretory Systems.- Insulin Release.- Corticosteroids.- Thyroid Hormone..- Pituitary Trophic Hormones.- Parathyroid Hormone and Calcitonin.- Conclusions.- 3 Nature of the Role of Calcium in Secretion.- Mechanism of Secretion.- Mode of Calcium Action.- Physical Theories.- Chemical Theories.- Microtubular-Microfilamentous System.- Cytoplasmic Motility.- Conclusions.- 4 Role of Cyclic AMP in the Secretory Process.- Effects of Exogenous Cyclic Nucleotide.- Phosphodiesterase Inhibition.- Measurement of Cyclic AMP Levels.- Interaction between Calcium and Cyclic AMP.- Prostaglandins.- Conclusions.- References.
Zusatzinfo | 39 black & white illustrations, biography |
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Sprache | englisch |
Maße | 150 x 230 mm |
Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Diabetologie |
Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie | |
Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
ISBN-10 | 0-306-30778-2 / 0306307782 |
ISBN-13 | 978-0-306-30778-2 / 9780306307782 |
Zustand | Neuware |
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