Gynecologic Endocrinology

Buch | Hardcover

716 Seiten

1987 | 4th edition
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-42189-1 (ISBN)

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It has been exactly five years since I was privileged to write the foreword for the previous edition of this distinguished book on gynecologic endocrinology. Reproductive endocrinology has been established as a separate respected area in the general field of endocrinology, as well as in obstetrics and gynecology. Years ago the reproductive endocrinologist took long periods of time to answer questions, since most of the studies done then used bioassay methods. These studies were hastened by the work of Berson and Yalow with their development of the radioimmunoassay. They were later awarded the Nobel Prize for this work, since it unlocked many avenues of investigation in the field of endocrinology. It is now possible to measure small quantities of hormones in various biological tissues. Since that time high-pressure liquid chro- matography and mass spectrometry have unlocked further secrets in this field with their capability of measuring ever smaller quantities of substances as well as their metabolites. Giant strides have been made in other diagnostic methods that interface with gynecologic endocrinology, notably in the field of radiology in the arena of tomography and CAT scans, and now nuclear magnetic resonance. Progress will be pushed still further, and this fourth edition again identifies the leading edge of knowledge. Such new areas embrace the physiology of relaxin, the ontogeny of sexual differentiation, diagnostic procedures on the cervix, functional dysmenorrhea and anorexia nervosa, idiopathic edema, and the misunderstood premenstrual tension syndrome.

I. Basic Anatomy and Physiology.- 1. Historical Introduction to Gonadal Regulation of the Uterus and the Menses.- 2. The Neuroendocrine System.- Historical Background.- Posterior Pituitary or Neurohypophysis.- Normal Physiology of the Anterior Pituitary and Median Eminence.- Pathophysiology.- Releasing Hormones and Their Use in Therapy.- Summary.- Questions.- References.- Answers.- 3. Placental Endocrinology.- Placental Steroid Hormones.- Placental Protein Hormones.- Other Placental Proteins.- Periplacental Hormones.- Summary.- Questions.- References.- Answers.- II. Hormonal Physiology.- 4. Hormonal Physiology of the Ovary and Adrenal Cortex.- Steroidogenesis in Ovary and Adrenal.- Germ Cell and Oocyte.- Folliculogenesis.- Estrogen and Hormone Receptors in Folliculogenesis.- Selection of the Preovulatory (Dominant) Follicle.- Ovulation.- Formation, Maintenance, and Lysis of the Corpus Luteum.- Luteinization Inhibitor and Stimulator.- Follicle Regulatory Protein.- Oocyte Maturation Inhibitor.- Inhibin (Inhibin F, Folliculostatin, Gonadostatin).- Prolactin.- Gonadotropin-Releasing Hormone.- Relaxin.- Questions.- References.- Answers.- 5. Physiology of Relaxin.- Structure.- Species Specificity.- Measurement of Relaxin.- Sources of Relaxin in the Human Female.- Relaxin in the Nonpregnant State.- Relaxin and Pregnancy.- Role of Relaxin in Women.- Relaxin in the Male.- Future Trends.- Summary.- Questions.- References.- Answers.- 6. Normal Growth and Development of the Female.- Development of the Sexually Undifferentiated Embryo.- Development of the Female Fetus.- Neuroendocrine Function in the Fetus.- Intrauterine Fetal Growth.- The Newborn Period.- Infancy and Childhood.- Peripubertal Hormonal Changes.- Neuroendocrine Development during Puberty.- Growth and Sexual Maturation during Puberty.- Summary.- Questions.- References.- Answers.- 7. Thyroid Function and Disease in the Female.- and Historical Background.- Thyroid Physiology.- Thyroid Function Tests.- Thyroid Pathophysiology.- Management of Thyroid Diseases.- The Thyroid in Pregnancy and the Postpartum.- Summary.- Questions.- References.- Answers.- III. Diagnostic Procedures.- 8. Hormone Assays in Endocrine Systems.- Procedures for Testing.- Hormone Assay Procedures.- Testing Protocols.- Future of Hormone Assay in Endocrinology.- Summary.- Questions.- References.- Answers.- 9. Hormonal Cytopathology of the Vagina.- Cytologic Techniques.- Cytology under Physiologic Conditions.- Assessment of Hormonal Effects.- Cytology of Pregnancy and Abortion.- The Menopause.- Cytology of Amenorrhea.- Effect of Hormonal Administration and Contraception.- Hormonal Patterns of Miscellaneous Conditions.- Summary.- Questions.- References.- Answers.- 10. Cervical Mucus.- Production and Physiochemical Properties.- Sperm Penetration of Cervical Mucus.- Antibacterial Activity of Cervical Mucus.- Use of Cervical Mucus in Clinical Tests of Infertility.- Cervicovaginal Peroxidases and Prediction of the Time of Ovulation.- Summary.- Questions.- References.- Answers.- 11. Endometrium.- Historical Considerations.- Normal Endometrium.- Endometrial Responses.- Other Dysfunctional Bleeding Syndromes.- Organic Pathology.- Summary.- Questions.- References.- Answers.- 12. Diagnostic Imaging.- Skeletal Age.- Hysterosalpingography.- Genitography.- Neuroendocrinology Imaging.- Adrenals.- Gynecologic Ultrasound.- Gonadal Dysgenesis.- Skeletal Abnormalities.- Visceral Anomalies.- Summary.- Questions.- References.- Answers.- 13. Endoscopic Procedures.- History and Background.- Laparoscopy.- Hysteroscopy.- Contact Hysteroscopy.- Summary.- Questions.- References.- Answers.- IV. Endocrine Disorders in the Female.- 14. Ovarian Dysgenesis and Related Genetic Disorders.- Genetic Control of Testicular and Ovarian Development.- General Considerations.- Pathologic Features of Monosomy X (45,X).- Specific Sex Chromosomal Abnormalities.- Gonadal Dysgenesis in 46,XX Individuals.- Gonadal Dysgenesis in 46,XY Individuals.- Miscellaneous Conditions.- Management.- Summary and Conclusions.- Questions.- References.- Answers.- 15. Female Pseudohermaphroditism in 21-Hydroxylase Deficiency.- Steroidogenesis and Enzymatic Conversions of Adrenal Steroid Hormones.- FetalSexual Development.- 21-Hydroxylase Deficiency.- Sex Assignment in Congenital Adrenal Hyperplasia.- Summary.- Questions.- References.- Answers.- 16. Hypothalamic-Pituitary Disease.- Hypothalamic-Pituitary Disorders.- Diagnosis of Hypothalamic-Pituitary Disease.- Questions for the Future.- Conclusion.- Questions.- References.- Answers.- 17. Secondary Amenorrhea and the Menopause.- Secondary Amenorrhea.- The Climacteric and Menopause.- Summary.- Questions.- References.- Answers.- 18. Endometriosis.- Historical Background.- Definition.- Incidence.- Pathogenesis.- Clinical Features.- Diagnosis.- Management.- Summary.- Questions.- References.- Answers.- 19. Dysmenorrhea and Prostaglandins.- Historical Aspects.- Definition and Classification.- Incidence.- Clinical Features.- Etiology of Dysmenorrhea.- Management.- Summary.- Questions.- References.- Answers.- 20. Fertility following Steroidal Oral Contraception and Diethylstilbestrol Exposure.- Postpill Amenorrhea Syndrome.- Reproductive Performance in Diethylstilbestrol-Exposed Women.- Summary.- Questions.- References.- Answers.- 21. Anorexia Nervosa and Other Weight-Loss-Associated Amenorrheas.- Pathophysiology.- Anorexia Nervosa.- Bulimia.- Simple Weight Loss.- Exercise-Induced Amenorrhea.- Summary.- Questions.- References.- Answers.- 22. Premenstrual Tension and Idiopathic Edema.- Premenstrual Tension: The Problem.- Pathophysiology.- Evaluation of the Patient with PMS.- Therapy.- Idiopathic Edema.- Summary.- Questions.- References.- Answers.- 23. Hirsutism and Virilism in Women.- Hirsutism.- Origin of Testosterone in Normal Women.- Androgen Excess in Hirsutism.- Androgen Metabolism in the Skin.- Testosterone Clearance versus Hirsutism.- Causes of Virilization in Women.- Clinical Clues in Evaluating Hirsutism.- Laboratory Tests for Virilization.- Treatment.- Summary.- Questions.- References.- Answers.- 24. Lactation and Galactorrhea.- Galactorrhea.- Definition and Diagnosis of Galactorrhea.- Causes of Galactorrhea.- Microadenomas.- Large Tumors.- Pregnancy and Pituitary Tumors.- Idiopathic Galactorrhea with Menses.- Idiopathic Galactorrhea with Amenorrhea.- Chiari-Frommel Syndrome.- Surgery and Trauma.- Drugs.- Hypothyroidism.- Empty Sella Syndrome.- Miscellaneous.- Treatment of Galactorrhea with Prolactin-Lowering Ergot Drugs.- Summary.- Questions.- References.- Answers.- 25. Hormone-Producing Tumors of the Ovary and Placenta.- Ovarian Tumors.- Placental Tumors (Gestational Trophoblastic Disease).- Summary.- Questions.- References.- Answers.- 26. Steroid Receptors in Breast, Uterine, and Ovarian Malignancy: Diagnostic and Therapeutic Applications.- Hormonal Control of Growth of Reproductive Tissues.- Breast Cancer.- Normal and Neoplastic Uterus.- Steroid Receptors and Ovarian Tumors.- Summary.- Questions.- References.- Answers.- 27. Understanding and Managing of Pregnancy in Women with Diabetes Mellitus.- Metabolic Changes in Pregnancy.- Detection of Diabetes.- Insulin-Dependent Diabetes Mellitus.- Gestational Diabetes.- Family Planning.- Summary.- Questions.- References.- Answers.- V. Infertility and its Future.- 28. Investigation of the Infertile Couple.- Investigation of Infertility.- Investigation of the Female.- Investigation of the Male.- Further Studies for Unexplained Infertility.- Summary.- Questions.- Answers.- 29. Male Infertility.- Male Physiology.- Androgen Production by the Testis.- Disorders of Testicular Function Associated with Infertility.- Diagnostic Evaluation of the Infertile Male.- Laboratory Evaluation of Testicular Function.- Summary of Therapeutic Intervention.- Summary.- Questions.- References.- Answers.- 30. Surgical Treatment of Infertility.- Pathophysiology.- Classification of Tubal Disease.- Classification of Operative Procedures.- Reparative Tubal Surgery.- Assessment of Tubal Surgical Success.- Pelvic Endometriosis.- Leiomyomata Uteri.- Metroplasty.- Summary.- References.- 31. Medical Treatment of Infertility.- Clomiphene Citrate.- Human Menopausal Gonadotropin.- Combined Clomiphene and hMG.- Gonadotropin-Releasing Hormone.- Bromocriptine.- Summary.- Questions.- References.- Answers.- 32. In Vitro Fertilization.- and Overview.- Historical Background.- Psychologic Principles Employed.- Clinical Methods and Procedures.- The Natural Cycle.- Stimulation of Ovulation.- Oocyte Retrieval and Aspiration Device.- Follicular Fluid and Oocyte Characteristics at Aspiration.- Transfer.- Results.- Summary.- References.- VI. New Frontiers in Gynecologic Endrocrinology.- 33. Endocrine Control of the Secretory Immune System in the Reproductive Tract of the Female: Response of IgA, IgG, and Secretory Component in the Uterus to Sex Hormones.- The Immune System in the Female Reproductive Tract.- Hormonal Influence on the Secretory Immune System of the Female Reproductive Tract.- Effect of Estradiol on IgA and IgG Levels in the Uterus of the Rat.- Cellular Aspects of the Immunoglobulin Response to Estradiol.- Effect of Estradiol and Progesterone on Secretory Component.- Levels of Secretory Component in Human Uterine Fluid during the Menstrual Cycle.- Effects of Steroid Hormones on Systemic Cellular and Humoral Immune Responses.- Conclusions.- Questions.- References.- Answers.- 34. Epidermal Growth Factor and Its Receptor and Their Possible Relationships to Gynecologic Endocrinology.- Epidermal Growth Factor.- The EGF Receptor.- Summary.- Questions.- References.- Answers.- Glossary of Abbreviations.

Erscheint lt. Verlag	31.1.1987
Zusatzinfo	716 p.
Verlagsort	New York
Sprache	englisch
Gewicht	1720 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe
	Medizinische Fachgebiete ► Innere Medizin ► Diabetologie
	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
ISBN-10	0-306-42189-5 / 0306421895
ISBN-13	978-0-306-42189-1 / 9780306421891
Zustand	Neuware