Hippocampal Microcircuits

A Computational Modeler's Resource Book

Vassilis Cutsuridis, Bruce Graham, Stuart Cobb, Imre Vida (Herausgeber)

Buch | Softcover

617 Seiten

2012 | 2010 ed.
Springer-Verlag New York Inc.
978-1-4614-2562-5 (ISBN)

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Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides succinct and focused reviews of experimental results. It is an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject’s experimental background, leading neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Here, ensemble activity, related to behavior, on the part of morphologically identified neurons in anesthetized and freely moving animals, lead to insights into the functions of hippocampal areas. In the second section, on computational analysis, computational neuroscientists present models of hippocampal microcircuits at various levels of detail, including single-cell and network levels. A full chapter is devoted to the single-neuron and network simulation environments currently used by computational neuroscientists in developing their models.

In addition to the above, the chapters also identify outstanding questions and areas in need of further clarification that will guide future research by computational neuroscientists.

Dr. Vassilis Cutsuridis is a Research Fellow in the Department of Computing Science and Mathematics at the University of Stirling, Scotland, UK. Bruce P. Graham is a Reader in Computing Science in the Department of Computing Science and Mathematics at the University of Stirling. Stuart Cobb is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow, Scotland, UK. Imre Vida is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow.

Preface
Part I
1.Introduction-Experimental background
2.Connectivity of the hippocampus
3.Cell morphologies
4.Physiological properties of hippocampal neurons
5.Glutamatergic neurotransmission in the hippocampus
6.Fast and slow GABAergic transmission in hippocampal circuits
7.Synaptic plasticity at hippocampal synapses
8.Neuromodulation of hippocampal cells and circuits
9.Neuronal Activity Patterns during Hippocampal Network Oscillations in Vitro
10.Neuronal Activity Patterns of Anaesthetized Animals
11.Spatial and behavioral correlates of hippocampal neuronal activity: A primer for computational analysis
Part II
12.Introduction-Computational Analysis
13.The making of a detailed CA1 pyramidal neuron model
14.CA3 cells: Detailed and simplified pyramidal cell models
15.Entorhinal cortex cells
16.Single Neuron Models: Interneurons
17.Gamma and Theta Rhythms in Biophysical Models of Hippocampal Circuits
18.Associative memory models
19.Microcircuit model of the dentate gyrus in epilepsy
20.Multi-level models
21.Biophysics-based models of LTP/LTD
22.A phenomenological calcium-based model of STDP
23.Computer simulation environments

Erscheint lt. Verlag	4.5.2012
Reihe/Serie	Springer Series in Computational Neuroscience ; 5
Zusatzinfo	61 Tables, black and white; XI, 617 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Gewicht	955 g
Themenwelt	Mathematik / Informatik ► Informatik ► Web / Internet
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Computational Neuroscience • declarative memories • hippocampus • Microcircuits • synaptic properties
ISBN-10	1-4614-2562-X / 146142562X
ISBN-13	978-1-4614-2562-5 / 9781461425625
Zustand	Neuware