Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment
Oxford University Press Inc (Verlag)
978-0-8412-2645-6 (ISBN)
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The metabolism of modern agrochemicals in animals, plants, and the environment have been extensively studied and reported in the literature by scientists. The results of a considerable number of these studies have been presented at National ACS, AGRO Division meetings and eventually published in the Journal of Agricultural and Food Chemistry, the ACS Symposium Series, as well as other ACS journals and books. These studies support the current registrations and use of
pesticides in the United States and worldwide. The integration of metabolism and toxicological studies in assessing human risks to pesticides is best performed using predictive physiological pharmacokinetic/pharmacodynamic and QSAR models. Physiological, biochemical, and toxicological parameters are
required for model development and is the subject of the chapters in this book. The book will update the scientific community in the development of the parameters required by pesticide PBPK/PD models and their application in model development, simulation, and risk assessment.
James P. Knaak is a professor at SUNY at Buffalo.
Preface ; Introduction ; 1. Parameters for Pesticide QSAR and PBPK/PD Models To Inform Human Risk Assessments ; M. R. Goldsmith, J. C. Johnson, D. T. Chang, R. Tornero-Velez, J. B. Knaak, and Curtis C. Dary ; Chiral Isomers/Toxicity/Separation/Metabolism ; 2. Chiral Chemistry and Toxicity Assessments for Pyrethroid Pesticides ; Robert W. Gerlach ; 3. Direct Chiral Separation of Pyrethroid Isomers by HPLC with Chiral Stationary Phases ; Masahiko Okamoto ; 4. Biotransformation and Enzymes Responsible for Metabolism of Pyrethroids in Mammals ; Hideo Kaneko ; Protein Binding, Gastrointestinal Absorption, Blood Brain Permeability, and Transport ; 5. The Influence of Maturation on Rat and Human Physiological Processes Involving Protein and Lipoprotein Binding, Gastrointestinal Absorption, and Blood Brain Permeability and Transport of Pyrethroids ; J. V. Bruckner, T. G. Osmitiz, S. Anand, D. Minnema, W. Schmitt, N. Assaf, and J. Zastre ; Percutaneous Absorption ; 6. 15 Factors of Percutaneous Penetration of Pesticides ; Mai A. Ngo and Howard I. Maibach ; 7. Mechanisms of Percutaneous Absorption of Pesticide Formulations ; William G. Reifenrath ; Liver/Tissue Metabolic Enzymes ; 8. Human Metabolic Interactions of Pesticides: Inhibition, Induction, and Activation ; Ernest Hodgson and Andrew D. Wallace ; 9. Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics ; Clement E. Furlong, Rebecca J. Richter, Lucio G. Costa, and Gail P. Jarvik ; 10. Carboxylesterases: A Multifunctional Enzyme Involved in Pesticide and Lipid Metabolism ; Matthew K. Ross and Mariola J. Edelmann ; Neurotoxicity I ; 11. Behavioral Changes in Adult and Young Rats as Indications of Cholinesterase Inhibition ; Virginia C. Moser ; 12. Comparison of Esterase Sensitivity, Metabolic Efficiency, and Toxicity Levels of Two Organophosphorus Insecticides: Parathion and Chlorpyrifos ; Janice E. Chambers, Edward C. Meek, and Howard W. Chambers ; 13. Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat ; Charles Timchalk, Jordan Ned Smith, Andrea Hjerpe, Torka S. Poet, and Sookwang Lee ; Neurotoxicity II ; 14. Pyrethroid Actions on Sodium Channels: Isoform and Species Specificity ; David M. Soderlund ; 15. Extrapolating Dose in Vitro to Dose in Vivo of a Neurotoxic Pyrethroid Pesticide Using Empirical Approaches and a PBPK Model ; Michael F. Hughes, Melissa P. L. Chan, James M. Starr, Timothy J. Shafer, Edward J. Scollon, and Michael J. DeVito ; QSAR/Other Models ; 16. In Silico Strategies for Modeling Stereoselective Metabolism of Pyrethroids ; Daniel T. Chang, Michael-Rock Goldsmith, Rogelio Tornero-Velez, Yu-Mei Tan, Christopher M. Grulke, Ling-Jen Chen, Elin M. Ulrich, Andrew B. Lindstrom, Melissa A. Pasquinelli, James R. Rabinowitz, and Curtis C. Dary ; 17. Quantitative Structure-Activity Relationships for Organophosphate Enzyme Inhibition ; Christopher D. Ruark, C. Eric Hack, Peter J. Robinson, and Jeffery M. Gearhart ; 18. Computational Approaches for Developing Informative Prior Distributions for Bayesian Calibration of PBPK Models ; Jimena L. Davis, Rogelio Tornero-Velez, and R. Woodrow Setzer ; PBPK/PD Models ; 19. Use of Cytochrome P450-Specific Parameters and Human Biomarker Data To Develop a Human Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Dermal Chlorpyrifos Exposure ; Corie A. Ellison, James B. Knaak, Robin McDougall, and James R. Olson ; 20. Use of in Vitro Data in PBPK Models: An Example of in Vitro to in Vivo Extrapolation with Carbaryl ; Miyoung Yoon, Gregory L. Kedderis, Yuching Yang, Bruce C. Allen, Grace Z. Yan, and Harvey J. Clewell ; Editors' Biographies ; Indexes ; Author Index ; Subject Index
| Erscheint lt. Verlag | 14.3.2013 |
|---|---|
| Reihe/Serie | ACS Symposium Series ; 1099 |
| Zusatzinfo | 121 black-and-white; 10 color |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 158 x 230 mm |
| Gewicht | 628 g |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie |
| Naturwissenschaften ► Chemie | |
| Weitere Fachgebiete ► Land- / Forstwirtschaft / Fischerei | |
| ISBN-10 | 0-8412-2645-8 / 0841226458 |
| ISBN-13 | 978-0-8412-2645-6 / 9780841226456 |
| Zustand | Neuware |
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