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Equine Metabolic Syndrome

(Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses

Tobias Warnken (Autor)

Buch

118 Seiten

2018
Cuvillier Verlag
978-3-7369-9806-3 (ISBN)

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Variations in insulin regulation reflect either as tissue insulin resistance or insulin dysregulation result in moderate to severe hyperinsulinemia in horses and ponies suffering from the Equine Metabolic Syndrome (EMS). Several pathomechanisms provoking equine insulin resistance have been suggested, but insulin signaling in healthy horses has not been studied in detail so far. Thus the objective of this PhD project was to investigate equine insulin sensitivity, glucose homeostasis and lipid metabolism by combining examinations of insulin signaling on a protein level in different main metabolic tissues and analyses of dynamic hormone and metabolite changes during acute stimulations by either oral glucose application or IV insulin and glucose injection. Furthermore, systemic markers of insulin resistance were analyzed by an innovative targeted metabolomics approach to provide better understanding of potential pathomechanisms involved in impaired insulin regulation in horses. In conclusion, equine-specific insulin signaling, the marginal relationship of insulin sensitivity to obesity and strong associations of high plasma insulin concentration to cellular oxidative stress depicted not only a special physiological condition but also indicate novel pathophysiological conditions underlying EMS.

Erscheinungsdatum	11.06.2018
Reihe/Serie	Wissenschaftliche Reihe der Klinik für Pferde ; 39
Verlagsort	Göttingen
Sprache	englisch
Maße	148 x 210 mm
Themenwelt	Veterinärmedizin ► Pferd
Schlagworte	Equine Metabolic Syndrome • Glucose homecstasis • insulin dysregulation • insulin resistance • insulin sensitivity • insulin signaling • Lipid metabolism • Metabolome
ISBN-10	3-7369-9806-6 / 3736998066
ISBN-13	978-3-7369-9806-3 / 9783736998063
Zustand	Neuware