Variant Haemoglobins (eBook)

A Guide to Identification

Barbara J. Bain, Lorraine Phelan, Adrian Stephens, Barbara Wild (Autoren)

eBook Download: PDF

2010 | 1. Auflage
200 Seiten
Wiley (Verlag)
978-1-4443-2832-5 (ISBN)

Infos

Variant Haemoglobins A Guide to Identification is based on the premise that any single diagnostic technique offers only a very provisional identification of a variant haemoglobin. In routine diagnostic practice two techniques are needed as a minimum, with the results being interpreted in the light of the clinical details, blood count, blood film and ethnic origin. This book covers 150 normal and variant haemoglobins that have been studied and carefully documented. Variant Haemoglobins has four introductory chapters followed by an invaluable atlas. The introductory chapters cover the genetics of haemoglobin synthesis the principles of tests employed for identification common haemoglobins of major clinical or diagnostic importance thalassaemias and related conditions The atlas section comprises 170 full colour pages in which each variant haemoglobin or combination of haemoglobins is illustrated by cellulose acetate electrophoresis at alkaline pH, agarose gel electrophoresis at acid pH, isoelectric focusing and one or more HPLC traces. For ease of reference, the atlas pages are arranged according to the retention time of each haemoglobin on HPLC, this becoming increasingly the primary technique employed in haemoglobin identification. Bringing a mix of necessary scientific expertise and clinical knowledge, each author has more than 30 years experience in the diagnosis of variant haemoglobins. Providing otherwise unavailable information, this unique and practical guide is illustrated with over 700 high quality colour digital images plus flow charts and line diagrams covers common and important haemoglobin variants, in addition to many rarer ones is an essential reference source for diagnosis in the haematology laboratory A remarkably useful book, Variant Haemoglobins will be valuable for haematopathologists, clinical and laboratory haematologists in practice and in training and all laboratory staff involved in haemoglobinopathy diagnosis.

Autor

Barbara J.Bain MB BS, FRACP, FRCPath Professor of Diagnostic Haematology St Mary's Hospital Campus of Imperial College Faculty of Medicine St Mary's Hospital London Barbara J. Wild PhD FIBMS Clinical Scientist Haemoglobinopathy Genetics Centre University College Hospitals London NHS Foundation Trust London Adrian D. Stephens MB BS, MD, FRCPath Honorary Consultant Haematologist University College London Hospitals NHS Foundation Trust London Lorraine Phelan MIBMS Haemoglobinopathy BMS Lead Haematology Laboratory, St Mary's Hospital Imperial College Healthcare NHS Trust London

Inhalt

Preface.

1 Globin genes and haemoglobin.

2 Diagnostic procedures and principles of commonly used
tests.

3 Common haemoglobins of major clinical or diagnostic
importance.

4 The thalassaemias and related conditions.

Atlas pages.

Technical notes to aid in interpretation of the following atlas
pages -- Please read first!

Table technical notes.

Index.

Rezensionen

"Nevertheless, this is a very helpful guide and will be of great
service to hospital diagnostic laboratories undertaking the
analysis of variant haemoglobins around the world. Indeed one hopes
an overseas edition will be produced for use in the less affluent
parts of the globe." (ACP News, 1 March 2012)

Produkt-Details

• Erscheint lt. Verlag: 16.9.2010
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
• Themenwelt: Veterinärmedizin
• Schlagworte: Hämatologie • Hämatologisches Labor • Hämatologie • Hämatologisches Labor • laboratory hematology • Medical Science • Medizin
• ISBN-10: 1-4443-2832-8 / 1444328328
• ISBN-13: 978-1-4443-2832-5 / 9781444328325