Single Molecule Biology

Buch | Hardcover

368 Seiten

2008
Academic Press Inc (Verlag)
978-0-12-374227-8 (ISBN)

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Describes such single molecule techniques (that allow for manipulation and measurement of single biological molecules within a live cell) as single molecule fluorescence, optical tweezers, and scanning probe microscopy. This book is organized by biological system or molecule. It discusses applications in molecular diagnostics and drug discovery.

Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective.The contents are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery.

Introduction and Historical Perspective
Motor Proteins: Linear Motors
Actin and Tubulin-Based Motors
DNA Motors
Rotary Motors
Single Molecule Enzymology
Ribozymes
Ribosomes
Large Complexes
Membrane Proteins
Channels and Pores
Cytoskeleton
DNA Mechanics and Structure
Single Molecules in Cells
Hair Cells
Structure of Single Protein Molecules
Single Molecule Mechanical Properties
Single Molecule Applications: Diagnostics
Single Molecule Applications: Arrays
Single Molecule Applications: Drug Discovery

Erscheint lt. Verlag	12.12.2008
Verlagsort	San Diego
Sprache	englisch
Maße	175 x 244 mm
Gewicht	900 g
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	0-12-374227-7 / 0123742277
ISBN-13	978-0-12-374227-8 / 9780123742278
Zustand	Neuware