Microarray Technology and Cancer Gene Profiling

Buch | Hardcover

159 Seiten

2006
Springer-Verlag New York Inc.
978-0-387-39977-5 (ISBN)

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Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.

Microarray Technology.- Manufacturing of Microarrays.- Technological Platforms for Microarray Gene Expression Profiling.- Principles of Gene Microarray Data Analysis.- Gaining Weights ... and Feeling Good about It!.- Complementary Techniques.- Complementary Techniques.- Complementary Techniques.- Applications in the Oncology Field.- Microarrays for Cancer Diagnosis and Classification.- Gene Profiling for the Prediction of Tumor Response to Treatment.- Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs.- SNP and Mutation Analysis.- Cancer Development and Progression.- Gene Expression Profiling in Malignant Lymphomas.- Tumor Immunology.

Erscheint lt. Verlag	4.12.2006
Reihe/Serie	Advances in Experimental Medicine and Biology ; 593
Zusatzinfo	XVIII, 159 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	165 x 248 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	0-387-39977-1 / 0387399771
ISBN-13	978-0-387-39977-5 / 9780387399775
Zustand	Neuware