CAR-T Manufacturing

Technologies and Innovations

Buch | Hardcover

208 Seiten

2025
CRC Press (Verlag)
978-1-032-66076-9 (ISBN)

Noch nicht erschienen (ca. Februar 2025)
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This edited volume describes innovations in all steps of the CAR-T manufacturing chain. These vital descriptions will help practitioners to overcome current challenges during the process and vastly reduce costs and enable timely and accessible administration of CAR-T therapy to patients.

The book provides readers with information on key fundamental concepts of CAR-T manufacturing in areas such as cell selection, cell activation, cell transfection, cell expansion, genetic engineering, and quality control. In each chapter, different experts cover a particular technological field in the CAR-T manufacturing chain. Each chapter will include an introduction to the importance of a particular technology for cell manufacturing, comparisons of state-of-the-art methods, and discussions on emerging innovations of that particular technology. This exposes readers to a high-level view of the entire process while diving into details for each specific process step. Readers will be able to apply their knowledge to make changes at each step of the CAR-T manufacturing process to reduce the currently high costs and long production times, so that cancer patients globally can benefit from CAR-T therapy.

This book is an invaluable resource for practitioners in CAR-T manufacturing who aim to improve their quality and efficiency while reducing time and costs. It is also useful for advanced undergraduate and graduate students who wish to gain a strong foundation for continuing research in the field or interacting with practitioners.

Andy Tay is a Presidential Young Professor in the Department of Biomedical Engineering at the National University of Singapore (NUS) and Principal Investigator at the Institute of Health Innovation & Technology and NUS Tissue Engineering Programme. He obtained his Bachelor’s degree from NUS and his PhD from UCLA in 2014 and 2017, respectively.

1. Immune cell selection and Isolation 2. Strategies for T cell Activation 3. Genetic tools to engineer CAR-T cells: Lessons from clinical studies 4. Intracellular delivery methods for therapeutic immune T-cell engineering 5. Bioreactor technology for CAR T cell manufacturing 6. Quality Control of CAR-T Products 7. Advances for in vivo CAR-T manufacturing

Erscheint lt. Verlag	6.2.2025
Zusatzinfo	8 Tables, black and white; 16 Line drawings, black and white; 16 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	174 x 246 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Technik ► Medizintechnik
ISBN-10	1-032-66076-7 / 1032660767
ISBN-13	978-1-032-66076-9 / 9781032660769
Zustand	Neuware