Principles of Molecular Probe Design and Applications

Wellington Pham (Autor)

Buch | Softcover

317 Seiten

2023 | 1st ed. 2023
Springer Verlag, Singapore
978-981-19-5741-3 (ISBN)

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This book describes insight mechanisms for designing molecular probes and methods that these agents can be used for medical diagnosis in preclinical animal models via optical, MRI and PET imaging. The book has a wealth of schemes of synthesis and methods deduced from pioneers in the field, making it possible to immerse into real-world molecular imaging. Written for graduate student training and practitioners, this book will serve as a teaching material and/or reference for anyone interested in exploring the power of chemical synthesis of imaging agents.

Wellington Pham received a Ph.D. degree in Medicinal Chemistry from the University of Toledo. His postdoctoral training focused on PET chemistry at The Crump Institute for Molecular Imaging, UCLA Medical School, followed by two postdoctoral trainings in molecular imaging at the Center of Molecular Imaging Research and the Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School. Currently, he is Professor of Radiology at Vanderbilt University Medical Center and holds joint appointments in the Departments of Biomedical Engineering, Vanderbilt Ingram Cancer Center, and Vanderbilt Brain Institute. He served on several steering committees and conference organizers on molecular imaging and molecular probes and a recipient of the Distinguished Investigator Award of the Academy for Radiology & Biomedical Imaging Research (2019). His research interests include the discovery of biomarkers and imaging probes, combined with delivery technologies dedicated to cancer and Alzheimer’s disease, and he has published nearly 150 publications, including peer-reviewed articles, book chapters, conference abstracts/proceedings, editorials, and patents on these subjects. His research has been funded by NIH, DOD, VA grants, and ADEKA Corporation.

Chapter 1: Overview of the fundamentals of chemistry for molecular probe design.- Chapter 2: Principles for the design of fluorescent dyes.- Chapter 3: Principles for the design of PET probes.- Chapter 4: Principles for the design of MRI probes.- Chapter 5: Solid-phase chemistry.- Chapter 6: Construction of molecular probes and imaging applications

Erscheinungsdatum	11.10.2023
Zusatzinfo	50 Illustrations, color; 216 Illustrations, black and white; IX, 317 p. 266 illus., 50 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Naturwissenschaften ► Physik / Astronomie ► Atom- / Kern- / Molekularphysik
	Technik ► Medizintechnik
Schlagworte	FRET Probes • molecular probes • Near-infrared Dyes • PET Chemistry • “Smart” Activated Probes • targeted imaging
ISBN-10	981-19-5741-X / 981195741X
ISBN-13	978-981-19-5741-3 / 9789811957413
Zustand	Neuware