Chirality in Drug Design and Development

Indra K. Reddy, Reza Mehvar (Herausgeber)

Buch | Hardcover

464 Seiten

2004
Crc Press Inc (Verlag)
978-0-8247-5062-6 (ISBN)

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Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Indra K. Reddy, Reza Mehvar

Foreword, Fakhreddin Jamali, Preface, Contributors, 1. Effects of Crystal Structure and Physical Properties on the Release of Chiral Drugs, 2. Use of Chiral Excipients in Formulations Containing Chiral Drugs, 3. Transport of Chiral Molecules Across the Skin, 4. Stereoselective Drug Delivery Through Prodrug Approach, 5. Stereoselectivity in Drug Action and Disposition: An Overview, 6. Stereospecific Pharmacokinetics and Pharmacodynamics: Selected Classes of Drugs, 7. Stereospecific Pharmacokinetics and Pharmacodynamics: Cardiovascular Drugs, 8. Chiral Inversion, 9. Bioequivalency Determination of Racemic Drug Formulations: Is Stereospecific Assay Essential?, 10. Regulatory Considerations in Drug Development of Stereoisomers, Index

Zusatzinfo	7 Halftones, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	152 x 229 mm
Gewicht	744 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik)
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie
	Technik
ISBN-10	0-8247-5062-4 / 0824750624
ISBN-13	978-0-8247-5062-6 / 9780824750626
Zustand	Neuware