Discrimination of Mobile Supramolecular Chirality
Acylative Molecular Transformations by Organocatalysis
Seiten
2021
|
1st ed. 2022
Springer Verlag, Singapore
978-981-16-7430-3 (ISBN)
Springer Verlag, Singapore
978-981-16-7430-3 (ISBN)
This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with perfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novelconcept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.
Introduction.- Mechanistic Study of Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol.- Discrimination of Mobile Supramolecular Chirality: Kinetic Resolution of Topologically Chiral Racemic Rotaxanes by Organocatalysis.- Conclusion and Perspective.
| Erscheinungsdatum | 29.11.2021 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | 35 Illustrations, color; 28 Illustrations, black and white; XIV, 87 p. 63 illus., 35 illus. in color. |
| Verlagsort | Singapore |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Naturwissenschaften ► Chemie ► Organische Chemie |
| Naturwissenschaften ► Chemie ► Physikalische Chemie | |
| Technik | |
| Schlagworte | asymmetric synthesis • molecular recognition • Molecular transformations • Rotaxane • Synthesis of chiral supramolecules |
| ISBN-10 | 981-16-7430-2 / 9811674302 |
| ISBN-13 | 978-981-16-7430-3 / 9789811674303 |
| Zustand | Neuware |
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