Magnetic Resonance and its Applications in Drug Formulation and Delivery

Michael D Mantle, Leslie P Hughes (Herausgeber)

Buch | Hardcover

418 Seiten

2024
Royal Society of Chemistry (Verlag)
978-1-78801-740-4 (ISBN)

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This book details the latest research and development in the use of magnetic resonance imaging and spectroscopy as tools to give quantitative insights concerning late stage pharmaceutical formulation, tablet manufacturing and drug dissolution behaviour. The book combines different facets of magnetic resonance and highlights the use of spatial resolution (MRI) and how this adds to the knowledge base to further our understanding of the microscopic physicochemical processes occurring during drug release from solid dosage forms.
New topics, that have not been thoroughly reviewed elsewhere, are covered including the applications of solution state magnetic resonance in process scale up, reaction monitoring/understanding and process analytical technologies (PAT); dissolution testing; and counterfeit analysis. Solid state NMR and its role in understanding phase separation in dispersions, polymorphism and crystallography are included and magnetic resonance imaging and its use in assessing tablet dissolution performance, mass transport and mixing in hot melt extrusion (HME) are covered.
Focusing on late stage development rather than molecular drug discovery provides a unique approach and the book will appeal to a diversity of disciplines using spectroscopy for study. Aimed at researchers in drug development, manufacture and formulation in both industry (pharmaceutical companies) and academia (pharmacy program), it includes examples, where appropriate, of studies on commercially available pharmaceutical products.

Applications of NMR in Drug Substance and Drug Product Development;The Application of Magnetic Resonance to Testing Counterfeit, Falsified and Substandard Medicines;Nuclear Quadrupole Resonance Spectroscopy in Pharmaceuticals;NMR Crystallography in Pharmaceutical Development;Using Water Proton NMR to Characterize Aluminum-adjuvanted Vaccines;Magnetic Resonance Methods Applied to the Study and Development of Cell Cultures and Bioreactors for Biopharmaceutical Production;Applications of Pulsed Field Gradient Nuclear Magnetic Resonance to Late-stage Pharmaceutical and Biopharmaceutical Development and Deployment;Applications of MRI to Study Controlled Drug Release Formulations: From Model Formulations Towards the Understanding of Drug Products Behaviour;Short-T2 Imaging Applications in Pharmaceutical Research

Erscheinungsdatum	19.03.2024
Reihe/Serie	New Developments in NMR ; Volume 33
Verlagsort	Cambridge
Sprache	englisch
Maße	156 x 234 mm
Gewicht	789 g
Themenwelt	Naturwissenschaften ► Chemie ► Analytische Chemie
Themenwelt	Technik
ISBN-10	1-78801-740-4 / 1788017404
ISBN-13	978-1-78801-740-4 / 9781788017404
Zustand	Neuware