Collagen Biografts for Tunable Drug Delivery

Rucha Joshi (Autor)

Buch | Softcover

XII, 107 Seiten

2021 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-63816-0 (ISBN)

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This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization.

Reviews state-of-the-art strategies for drug incorporation and retention in collagen ;
Covers collagen based material applications for improving vascularization and tissue regeneration;
Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.

Rucha Joshi, PhD, is a faculty in the Department of Biomedical Engineering at University of California, Davis, focusing on engineering education research and instructional innovation in biomedical engineering. Prior to joining UC Davis, she was post-doctoral fellow in the Weldon School of Biomedical Engineering at Purdue University, working on multiple educational projects in enhancing teaching, learning, outreach, and diversity of engineers. Prior to receiving her PhD from Purdue, she received an MS in Biomedical Engineering at Vanderbilt University and a BS in Biotechnology Engineering from Shivaji University, India. Dr. Joshi has received several scholarships and awards for thought leadership, entrepreneurship and community engagement, including the Ross Fellowship for outstanding PhD applicants, and the Burton D. Morgan Fellowship for entrepreneurial students at Purdue. She was honored by the late president of India, Dr. APJ Abdul Kalam for her invention of "Low calorie biscuits from banana peel pulp" and for her STEM popularization efforts. She authored a book summarizing her life experiences in inspiring Indian students towards STEM pursuits that won a literary award from Maharashtra State Government.

Introduction.- Creating Tunable Collagen Matrices - An Approach Inspired by In-Vivo Collagen Synthesis and Self-Assembly.- Application of Collagen Fibril Biografts for Enhancing Local Vascularization in an In-Vivo Chick Chorioallantoic Membrane (CAM) Model.- Appendix A: Type I Collagen Based Drug Delivery Formats.- Appendix B: State-of-the-Art Methods of Tuning Collagen Based Molecular Release.

Erscheinungsdatum	02.02.2021
Reihe/Serie	SpringerBriefs in Applied Sciences and Technology
Zusatzinfo	XII, 107 p. 41 illus., 30 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	195 g
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Technik ► Maschinenbau
Schlagworte	Affinity based drug retention • blood vessel formation • Chicken egg chorioallontoic membrane assay (CAM) • Collagen-based drug delivery • Collagen biografts • Collagen polymers for tissue engineering • Drug incorporation methods in collagen • Heparin • Neovascularization • Self-assembling polymer • vascular endothelial growth factor (VEGF) • Vascularization • wound healing
ISBN-10	3-030-63816-2 / 3030638162
ISBN-13	978-3-030-63816-0 / 9783030638160
Zustand	Neuware