Absorption and Drug Development

Solubility, Permeability and Charge State

Alex Avdeef (Autor)

Buch | Hardcover

312 Seiten

2003
John Wiley & Sons Inc (Verlag)
978-0-471-42365-2 (ISBN)

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Absorption and Drug Development

Alex Avdeef

2012

Buch | Hardcover

CHF 239, ⁹⁵

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Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules:* Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.* Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.

Alex Avdeef, PhD, is CEO and CSO of pION Inc., and has over thirty years of experience in chemical instrumentation and software development. He is an internationally know authority on solution chemistry and is the author of an extensive list of publications.

Preface. Acknowledgments. Definitions. 1. Introduction. 2. Transport Model. 3. Charge State. 4. Partitioning Into Octanol. 5. Partitioning Into Liposomes. 6. Solubility. 7. Permeability. 8. Summary and Some Simple Rules. References. Index.

Zusatzinfo	Illustrations
Verlagsort	New York
Sprache	englisch
Maße	164 x 236 mm
Gewicht	592 g
Einbandart	gebunden
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Naturwissenschaften ► Chemie
	Technik
ISBN-10	0-471-42365-3 / 0471423653
ISBN-13	978-0-471-42365-2 / 9780471423652
Zustand	Neuware