Design and Analysis of Animal Studies in Pharmaceutical Development

Shein-Chung Chow, Jen-Pei Liu (Herausgeber)

Buch | Softcover

408 Seiten

2020
Chapman & Hall/CRC (Verlag)
978-0-367-57938-8 (ISBN)

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"Provides well-integrated, comprehensive coverage of all the major statistical designs and methods used for animal studies in pharmaceutical research and development. Demonstrates the correct way to interpret the results of animal studies in the risk assessment of biopharmaceutical products and clarifies detailed presentations with real-world examples. "

Shein-Chung Chow, Jen-pei Liu

Experimental design principles for animal studies in pharmaceutical development; interval estimation with small samples for Median Lethal Dose (LD50) or Median Effective Dose (ED50); principles in statistical testing in randomized toxicological studies; subacute toxicity studies - proof of safety versus proof of hazard; design of long-term carcinogenicity studies; analysis of long-term carcinogenicity studies; design of reproductive studies; analysis of reproductive and development studies; the in vitro Ames tests; the in vitro Chinese hamster ovary cell mutagenesis studies.

Erscheinungsdatum	01.07.2020
Reihe/Serie	Chapman & Hall/CRC Biostatistics Series
Sprache	englisch
Maße	152 x 229 mm
Gewicht	453 g
Themenwelt	Mathematik / Informatik ► Mathematik
	Medizin / Pharmazie
	Naturwissenschaften ► Biologie ► Zoologie
	Technik
ISBN-10	0-367-57938-3 / 0367579383
ISBN-13	978-0-367-57938-8 / 9780367579388
Zustand	Neuware