Bone Cement (eBook)

From Simple Cement Concepts to Complex Biomimetic Design

Hamid Reza Rezaie, Mohammad Hossein Esnaashary, Masoud Karfarma, Andreas Öchsner (Autoren)

eBook Download: PDF

2020 | 1st ed. 2020
VIII, 88 Seiten
Springer International Publishing (Verlag)
978-3-030-39716-6 (ISBN)

Infos

This book provides an overview of the composition of polymeric and ceramic bone cements. It also discusses complex, biomimetic structures based on biomaterials, such as cells and bioactive molecules, which more closely resemble natural bone

The first chapter describes the main concepts of the cementation process and the parameters affecting it, while the second chapter focuses on the composition and structure of candidate biomaterials. Lastly, the third and fourth chapters present recent research aimed at improving the ability of naked biomaterials to enhance bone healing by adding cells and bioactive agents.

Inhalt

Preface 6
Contents 7
1 Cement Concept 9
1.1 Introduction 9
1.2 History 9
1.3 Medical History of Cement 11
1.4 Cement Applications 11
1.5 Why Bone Cement? 13
1.6 Bone Cement Properties 13
1.7 The Setting Process 16
1.8 The Effective Parameters 17
1.8.1 Powder to Liquid Ratio 17
1.8.2 Particle Size/Molecular Size 19
1.8.3 Reactant Reactivity 21
1.9 Tissue Engineering 22
References 23
2 Conductivity: Materials Design 26
2.1 Introduction 26
2.2 Bone 26
2.3 Bone Cement Compositions 27
2.3.1 Polymethyl Methacrylate 27
2.3.2 Polypropylene Fumarate 29
2.3.3 Calcium Phosphate Cement 30
2.3.4 Magnesium Phosphate Cement 32
2.3.5 Other Types of Cement 33
2.4 Scaffold 33
2.4.1 Properties 34
2.4.2 Production Methods 34
2.4.3 Bone Cement Scaffolds 37
References 44
3 Productivity: Cells 49
3.1 Introduction 49
3.2 Bone Cells 49
3.2.1 Stem Cell Niches in Bone 50
3.2.2 Resident Cells in the Bone 50
3.3 Cell Sources for Bone Tissue Engineering 53
3.3.1 Embryonic Stem Cells 53
3.3.2 Induced Pluripotent Stem Cells 54
3.3.3 Fetal Stem Cells 56
3.3.4 Adult Stem Cells 57
3.3.5 Osteoblasts and Osteoclasts 63
3.4 Cell-Seeding Techniques 65
3.4.1 Static Cell Seeding Method 65
3.4.2 Dynamic Cell Seeding 66
3.4.3 Magnetic Cell Seeding Method 66
3.5 Bioreactors 66
3.5.1 Spinner Flask Bioreactor 67
3.5.2 Rotating Wall Bioreactor 69
3.5.3 Hollow-Fiber Bioreactors 69
3.5.4 Perfusion Bioreactors 69
3.5.5 Compression Bioreactors 69
3.5.6 Combined Bioreactors 70
References 70
4 Inductivity: Bioactive Agents 75
4.1 Introduction 75
4.2 Growth Factors Involved in Bone Regeneration 76
4.3 Bioactive Agent Used in Bone Tissue Engineering 77
4.3.1 Growth Factors 78
4.3.2 Drugs 83
4.3.3 Nucleic Acids 86
4.3.4 Other Bioactive Agents 87
4.4 Bioactive Agent Incorporation Strategies 88
4.4.1 Non-covalent Bioagent Immobilization 89
4.4.2 Covalent Bioagent Immobilization 90
4.5 Challenges in Bone Tissue Engineering 90
References 91

Produkt-Details

• Erscheint lt. Verlag: 9.1.2020
• Reihe/Serie: SpringerBriefs in Applied Sciences and Technology
• Reihe/Serie: SpringerBriefs in Applied Sciences and Technology
• Zusatzinfo: VIII, 88 p. 52 illus., 39 illus. in color.
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Physik / Astronomie
• Themenwelt: Technik ► Maschinenbau
• Schlagworte: Bioactive Molecules • biomimetic structures • Bone healing • ceramic cement • polymeric cement
• ISBN-10: 3-030-39716-5 / 3030397165
• ISBN-13: 978-3-030-39716-6 / 9783030397166