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Drug Repositioning -

Drug Repositioning

Approaches and Applications for Neurotherapeutics

Joel Dudley, Laura Berliocchi (Herausgeber)

Buch | Softcover
313 Seiten
2019
CRC Press (Verlag)
978-0-367-86907-6 (ISBN)
CHF 125,65 inkl. MwSt
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Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet.



In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development.



For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders.



This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

Dr. Joel Dudley is associate professor of genetics and genomic sciences and director of biomedical informatics at Mount Sinai School of Medicine, New York (NY, USA). Dr. Laura Berliocchi is associate professor of pharmacology at the Department of Health Sciences, Magna Graecia University (Catanzaro, Italy).

Section I The Rationale and Economics



of Drug Repositioning



Chapter 1 Scientific and Commercial Value of Drug Repurposing

David Cavalla

Chapter 2 Repurposing for Alzheimer’s and Parkinson’s Diseases: The



Ideas, the Pipeline, the Successes, and the Disappointments

Hermann Mucke

Chapter 3 Contribution of Not-for-Profit Organizations to Drug Repurposing

Bruce Bloom

Section II Repositioning Approaches and



Technologies: From Serendipity to



Systematic and Rational Strategies



Chapter 4 Systematic Drug Repositioning

Spyros N. Deftereos, Aris Persidis, Andreas Persidis,



Eftychia Lekka, Christos Andronis, and Vassilis Virvillis

Chapter 5 Technical Tools for Computational Drug Repositioning

Francesco Napolitano

Chapter 6 RNAi Screening toward Therapeutic Drug Repurposing

Nichole Orr-Burks, Byoung-Shik Shim, Olivia Perwitasari,



and Ralph A. Tripp

Chapter 7 Phenotypic Screening

Christine M. Macolino-Kane, John R. Ciallella,



Christopher A. Lipinski, and Andrew G. Reaume

Section III Drug Repositioning for



Nervous System Diseases



Chapter 8 A Case Study: Chlorpromazine

Francisco López-Munoz, Cecilio Álamo,



and Silvia E. García-Ramos

Chapter 9 Drug Repurposing for Central Nervous System Disorders: A



Pillar of New Drug Discovery

Mondher Toumi, Aleksandra Caban, Anna Kapuśniak,



Szymon Jarosławski, and Cecile Rémuzat

Chapter 10 Repurposing Opportunities for Parkinson’s Disease Therapies

Giulia Ambrosi, Silvia Cerri, and Fabio Blandini

Chapter 11 Drug Candidates for Repositioning in Alzheimer’s Disease

Maria P. del Castillo-Frias and Andrew J. Doig

Erscheinungsdatum
Reihe/Serie Frontiers in Neurotherapeutics Series
Verlagsort London
Sprache englisch
Maße 156 x 234 mm
Gewicht 453 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Technik
ISBN-10 0-367-86907-1 / 0367869071
ISBN-13 978-0-367-86907-6 / 9780367869076
Zustand Neuware
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