Interaction of Nanomaterials with the Immune System

James C. Bonner, Jared M. Brown (Herausgeber)

Buch | Hardcover

X, 223 Seiten

2020 | 1st ed. 2020
Springer International Publishing (Verlag)
978-3-030-33961-6 (ISBN)

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This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

James C. Bonner is Professor of Toxicology at North Carolina State University. His research focuses on the fibroproliferative effects of nanomaterials in the lung, particularly in susceptible disease models. Jared M. Brown is Professor of Toxicology at the University of Colorado Anschutz Medical Campus. His research focuses on allergic immune responses to nanomaterials and their application in medicine.

Overview of immune response to nanomaterials caused by either inhalation, oral, or dermal exposure.- Engineered nanomaterials: synthesis, characterization, uses and exposure.- Impact of nanomaterials on barrier function.- Complement activation and inflammation.- Macrophage function and phagocytosis.- Mast cells.- Impact on dendritic cell - lymphocyte function.- Impact on host pathogen response and microbiome.- Allergy/autoimmunity.- Pre-existing allergic or bacterial-induced lung disease.- Nanomaterial effects on viral infection.- Immunotoxicity and carcinogenesis.- In vivo animal models (nude mice, transgenic models).- In vitro cell culture models.- In silico computational modeling.- Summary of mechanisms of immune modulation.

Erscheinungsdatum	02.02.2020
Reihe/Serie	Molecular and Integrative Toxicology
Zusatzinfo	X, 223 p. 16 illus., 5 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	511 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Technik
Schlagworte	Carcinogenesis • Computational modeling • Disease models • Engineered nanomaterials • fibroproliferative • immune response • immunotoxicity testing • macrophage
ISBN-10	3-030-33961-0 / 3030339610
ISBN-13	978-3-030-33961-6 / 9783030339616
Zustand	Neuware