New Developments in Tissue Engineering and Regeneration (eBook)

Paulo Rui Fernandes, Paulo Jorge da Silva Bartolo (Herausgeber)

eBook Download: PDF

2019 | 1st ed. 2019
VII, 86 Seiten
Springer International Publishing (Verlag)
978-3-030-15372-4 (ISBN)

Infos

This volume presents a new contribution for the field of Tissue Engineering with a focus on the development of mathematical and computational methods that are relevant to understand human tissues, as well to model, design, and fabricate optimized and smart scaffolds.

The multidisciplinary character of this field has motivated contributions from different areas with a common objective to replace damaged tissues and organs by healthy ones. This work treats tissue healing approaches, mathematic modelling for scaffold design and bio fabrication methods, giving the reader a broad view of the state of the art in Tissue Engineering.

The present book contains contributions from recognized researchers in the field, who were keynote speakers in the Fourth International Conference on Tissue Engineering, held in Lisbon in 2015, and covering different aspects of Tissue Engineering.

The book is strongly connected with the conference series of ECCOMAS Thematic Conferences on Tissue Engineering, an event that brings together a considerable number of researchers from all over the world, representing several fields of study related to Tissue Engineering.

Inhalt

Preface 6
Contents 7
Computational Modelling of Wound Healing Insights to Develop New Treatments 8
1 Introduction 9
2 Healthy Skin 10
3 Wound Healing 12
4 Severe Wound Treatments 14
5 Computational Models of Wound Healing 16
6 Discussion and Conclusions 21
References 23
Traction Force Microscopy in Differentiating Cells 27
1 Introduction 27
2 Cell Cytoskeleton and Force Generation 28
3 Cell Traction Force Measurements 28
3.1 Cell Traction Force Microscopy and Analysis 30
4 Mechanical Properties of Mesenchymal and Committed Cells 32
4.1 Traction Forces Exerted by Differentiating Adipocytes 33
5 Summary 35
References 35
Adaptive Multi-resolution Volumetric Modeling of Bone Micro-structure 37
1 Introduction 38
2 Approach 39
3 Implementation 40
4 Examples and Discussion 42
4.1 2D Examples—Adaptive Models 42
4.2 3D Examples—Bone Fragment Extraction 44
4.3 3D Examples—Multi-resolution Models 45
4.4 3D Examples—Curvature Analysis 45
4.5 Topological Preservation 47
4.6 3D Examples—Adaptive Models 52
5 Summary and Conclusions 54
References 55
Low Temperature 3D Printing of Drug Loaded Bioceramic Scaffolds and Implants 57
1 Introduction 57
2 3D Printing Technology 58
3 Material Approaches to 3D Powder Printing of Ceramic Bone Scaffolds 61
4 Drug Modification of 3D Printed Implants 63
5 Conclusion 66
References 68
A Biomechanical Approach for Bone Regeneration Inside Scaffolds Embedded with BMP-2 73
1 Introduction 73
2 Materials and Methods 74
2.1 Degradation Model 75
2.2 Bone Tissue Regeneration Model 76
2.3 Material Properties by Homogenization 78
3 Results 79
3.1 Results for Scaffolds Without BMP-2 79
3.2 BMP-2 Embedded Scaffolds. Comparison with Experimental Data 80
3.3 Results for Periodic Porous Scaffolds Embedded with BMP-2 80
4 Discussion 84
Appendix 87
References 91

Produkt-Details

• Erscheint lt. Verlag: 27.3.2019
• Reihe/Serie: Computational Methods in Applied Sciences
• Reihe/Serie: Computational Methods in Applied Sciences
• Zusatzinfo: VII, 86 p. 40 illus., 35 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Technik ► Maschinenbau
• Schlagworte: Biomanufacturing • biomaterials • computational biomechanics • Scaffold Design • Tissue engineering
• ISBN-10: 3-030-15372-X / 303015372X
• ISBN-13: 978-3-030-15372-4 / 9783030153724