Regenerative Medicine for Degenerative Muscle Diseases
Humana Press Inc. (Verlag)
978-1-4939-8001-7 (ISBN)
This book compiles and
explores cutting-edge research in degenerative skeletal disorders, such as
Duchenne muscular dystrophy and congenital myopathy, and new stem-cell based
therapies and gene replacement therapy. Twelve expertly-authored chapters navigate
the nuances of these treatments in an array of contexts and biological systems.
The topics covered include: How are urine cells from a patient with Duchenne
muscular dystrophy transformed into beating heart cells? What can reprogrammed
cells tell us about heart muscle failure? What do gene mutations mean for those
born with a muscle disease? How are manufacturing methods applied to human stem
cells? Does therapeutic exercise benefit those patients who receive engineered
limb muscle? Is there practical advice about nutrition to enhance muscle
function for the Duchenne patient? Can microRNAs be useful to regenerate
diseased muscle?
Regenerative
Medicine for Degenerative Muscle Diseases is ideal for scientists
and clinicians from varying disciplines in genetics, cell biology, virology,
cell-based manufacturing, rehabilitation medicine, nutrition, veterinary
medicine and neurosurgery. The reader will see how transformative changes occur
in medicine that can powerfully impact the future for patients suffering from
inherited disorders affecting muscles of the body, including the heart.
Martin K. (Casey) Childers, D.O., Ph.D. is a professor in the Department of Rehabilitation Medicine and Investigator at the Institute for Stem Cell & Regenerative Medicine, University of Washington. He is a graduate of Seattle Pacific University (B.A., Music Performance), Western University (D.O., Medicine, Osteopathic) and The University of Missouri (Ph.D., Physiology & Pharmacology; residency, Rehabilitation Medicine). The Childers' laboratory works in two areas of investigation. In a series of preclinical studies, they address the hurdles required for systemic gene replacement delivery for patients with X-Linked Myotubular Myopathy (XLMTM). In other studies, they use a "disease in a dish" approach with induced pluripotent stem (iPS) cells to study heart disease in patients with Duchenne muscular dystrophy (DMD). Dr. Childers clinical medicine practice at the University of Washington Medical Center is dedicated to serve patients with neuromuscular diseases.
Preface.- 1. Regenerative Medicine Approaches to Degenerative Muscle Diseases.- 2. An Overview of rAAV Vector Product Development for Gene Therapy.- 3. Gene Discovery in Congenital Myopathy.- 4. Stem Cell Transplantation for Degenerative Muscle.- 5. Spinal Cord Cellular Therapeutics Delivery: Device Design Considerations.- 6. Patient Derived Induced Pluripotent Stem Cells Provide a Regenerative Medicine Platform for Duchenne Muscular Dystrophy Heart Failure.- 7. Overview of Chemistry, Manufacturing and Controls (CMC) for Pluripotent Stem Cell-Based Therapies.- 8. Regenerative Rehabilitation: Synergizing Regenerative Medicine Therapies with Rehabilitation for Improved Muscle Regeneration in Muscle Pathologies.- 9. Practical Nutrition Guidelines for Individuals with Duchenne Muscular Dystrophy.- 10. Identifying Beneficial Drug Therapies for Muscle Disease Using Zebrafish.- 11. The Use of miRNAs in Muscle Diseases.- 12 Canine Inherited Dystrophinopathies and Centronuclear Myopathies.- Index.
| Erscheinungsdatum | 20.12.2018 |
|---|---|
| Reihe/Serie | Stem Cell Biology and Regenerative Medicine |
| Zusatzinfo | 23 Illustrations, color; 3 Illustrations, black and white; XIII, 336 p. 26 illus., 23 illus. in color. |
| Verlagsort | Totowa, NJ |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie |
| Technik ► Umwelttechnik / Biotechnologie | |
| Schlagworte | Cellular therapeutics • Muscle disease and disorder • Regenerative medicine • Skeletal muscle • Stem cell-based therapies |
| ISBN-10 | 1-4939-8001-7 / 1493980017 |
| ISBN-13 | 978-1-4939-8001-7 / 9781493980017 |
| Zustand | Neuware |
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