Numerical Pde Analysis Of The Blood Brain Barrier: Method Of Lines In R

William E Schiesser (Autor)

Buch | Hardcover

264 Seiten

2019
World Scientific Publishing Co Pte Ltd (Verlag)
978-981-327-579-9 (ISBN)

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The remarkable functionality of the brain is made possible by the metabolism (chemical reaction) of oxygen (O₂) and nutrients in the brain. These metabolism components are supplied to the brain by an intricate blood circulatory system (vasculature). The blood brain barrier (BBB), which is the central topic of this book, determines the rate of transfer from the blood to the brain tissue.In particular, mathematical models are developed for mass transfer across the BBB based on partial differential equations (PDEs) applied to the blood capillaries, the endothelial membrane, and the brain tissue. The PDEs derived from mass balances and computer routines in R are presented for the numerical (computer-based) solution of the PDEs. The computed concentration profiles of the transferred components are functions of time and space within the BBB system, i.e., spatiotemporal solutions.The R routines and the associated numerical algorithms for computing the numerical solutions are discussed in detail. The discussion is introductory, without formal mathematics, e.g., theorems and proofs. The general methodology (algorithm) for numerical PDE solutions is the method of lines (MOL).The models are used to study the transfer of oxygen and nutrients, harmful substances that should not enter the brain such as chemicals and pathogens (viruses, bacteria), and therapeutic drugs. The intent of the book is to provide a quantitative approach to the study of BBB dynamics using a computer-based methodology programmed in R, a quality open-source scientific programming system that is easily downloaded from the Internet for execution on modest computers.

Erscheinungsdatum	08.01.2019
Verlagsort	Singapore
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
Themenwelt	Technik ► Medizintechnik
ISBN-10	981-327-579-0 / 9813275790
ISBN-13	978-981-327-579-9 / 9789813275799
Zustand	Neuware