Enabling Precision Medicine

The Role of Genetics in Clinical Drug Development: Proceedings of a Workshop

Engineering National Academies of Sciences and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Roundtable on Genomics and Precision Health, Development Forum on Drug Discovery and Translation (Autoren)

Buch | Softcover

144 Seiten

2017
National Academies Press (Verlag)
978-0-309-46263-1 (ISBN)

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Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine.

On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.

Table of Contents

Front Matter
1 Introduction
2 Overarching Considerations for Implementing Successful Genetics-Enabled Drug Development
3 Case Studies in Precision Drug Development
4 Integrating Genetics into the Drug Development Pathway for Complex Diseases
5 Finding Innovative Ways to Integrate Genetic Research into the Drug Development Process
6 Reflecting Back and Looking Forward: Key Themes and Potential Next Steps in Genetics-Enabled Drug Development
Appendix A: References
Appendix B: Statement of Task and Workshop Agenda
Appendix C: Speaker Biographical Sketches
Appendix D: Registered Attendees

Erscheinungsdatum	09.11.2017
Verlagsort	Washington
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Medizin / Pharmazie ► Gesundheitswesen
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Technik ► Medizintechnik
ISBN-10	0-309-46263-0 / 0309462630
ISBN-13	978-0-309-46263-1 / 9780309462631
Zustand	Neuware