Boron Reagents in Synthesis
Oxford University Press Inc (Verlag)
978-0-8412-3183-2 (ISBN)
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Boron compounds have been used extensively in organic synthesis for more than sixty years. Some of the best known reactions in synthesis, such as the Suzuki-Miyaura cross-coupling and the hydroboration reaction, involve boron compounds. Several natural products containing boron have been isolated in the last fifty years, including ionophoric macrodiolide antibiotics boromycin, borophycin, aplasmomycins A, B, and C, and tartrolons B, C, and E, as well as
autoinducer-2. The study of compounds containing boronic acids for application in pharmaceuticals and materials science has grown tremendously over the last few decades. These include bortezomib, ixazomib, and tavaborole. Several more boron-based drugs are currently in clinical trials. Boron neutron capture
therapy has the potential to provide a treatment for various cancers. In addition, materials bearing boronic acids are been studied as potential sensors for biological molecules, such as saccharides and glycoproteins that possess cis-1,2- or cis-1,3-diols.
Adiel Coca obtained his BS degree from Iona College (New Rochelle, NY) in 2001 and later received a PhD in 2007 from Pennsylvania State University. After a one year visiting position at Franklin and Marshall College (Lancaster, PA), he took a position at Southern Connecticut State University in 2008 where he is currently an Associate Professor. He was a visiting researcher at Oxford University in 2015. Dr. Coca's current research interests include the synthesis of natural and unnatural heterocyclic compounds and the development of new antibiotics.
Preface
1. Boron Chemistry: An Overview
2. Lewis Acids
3. Allylboration
4. Boron Enolate Chemistry
5. Unstable Intermediates as Keys to Synthesis with Organoboron Compounds
6. Current Developments in the Catalyzed Hydroboration Reaction
7. Synthesis of Pinacolboronates via Hydroboration
8. Boron Hydride Reduction
9. The Petasis Borono-Mannich Multicomponent Reaction
10. Copper-Catalyzed Coupling Reactions of Organoboron Compounds
11. Introduction, Interconversion and Removal of Boron Protecting Groups
12. B-Protected Boronic Acids: Methodology Development and Strategic Application
13. Di- and Polyboron Compounds: Preparation and Chemoselective Transformations
14. Acylation Reactions of Organoborons
15. Development of Organic Transformations Based on Protodeboronation
Editor's Biography
Indexes
| Erscheinungsdatum | 09.02.2017 |
|---|---|
| Reihe/Serie | ACS Symposium Series |
| Zusatzinfo | 59 |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 161 x 230 mm |
| Gewicht | 870 g |
| Themenwelt | Naturwissenschaften ► Chemie ► Anorganische Chemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Technik ► Maschinenbau | |
| ISBN-10 | 0-8412-3183-4 / 0841231834 |
| ISBN-13 | 978-0-8412-3183-2 / 9780841231832 |
| Zustand | Neuware |
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