Biology, Computing, and the History of Molecular Sequencing

From Proteins to DNA, 1945-2000

M. García-Sancho (Autor)

Buch | Softcover

242 Seiten

2012 | 1st ed. 2012
Palgrave Macmillan (Verlag)
978-1-349-32122-3 (ISBN)

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Sequencing is often associated with the Human Genome Project and celebrated achievements concerning the DNA molecule. However, the history of this practice comprises not only academic biology, but also the world of computer-assisted information management. The book uncovers this history, qualifying the hype and expectations around genomics.

Miguel Garcia-Sancho obtained his Ph.D. at Imperial College London, UK, and has worked at the University of Manchester and Spanish National Research Council (CSIC). He is currently a Chancellor's Fellow at the Department of Science, Technology and Innovation Studies of the University of Edinburgh. His interests lay in the history and social studies of twentieth century biomedicine, as well as science communication and free-lance scientific journalism.

Introduction: An Historical Approach to Sequencing PART I: EMERGENCE: FREDERICK SANGER'S PIONEERING TECHNIQUES (1943-1977) The Sequence of Insulin and the Configuration of a New Biochemical Form of Work (1943-1962) From Chemical Degradation to Biological Replication (1962-1977) PART II: MECHANISATION – 1: COMPUTING AND THE AUTOMATION OF SEQUENCE RECONSTRUCTION (1962-1987) Sequencing Software and the Shift in the Practice of Computation Sequence Databases and the Emergence of 'Information Engineers' PART III: MECHANISATION – 2: THE SEQUENCER AND THE AUTOMATION OF SEQUENCE CONSTRUCTION (1980-2000) A New Approach to Sequencing at Caltech The Commercialisation of the DNA Sequencer Conclusions: A Long History of Practices Appendix 1: Oral Histories Appendix 2: Archival Sources Notes Bibliography

Erscheinungsdatum	26.05.2016
Reihe/Serie	Science, Technology and Medicine in Modern History
Zusatzinfo	XIII, 242 p.
Verlagsort	Basingstoke
Sprache	englisch
Maße	140 x 216 mm
Themenwelt	Sachbuch/Ratgeber ► Natur / Technik
	Geschichte ► Teilgebiete der Geschichte ► Kulturgeschichte
	Studium ► Querschnittsbereiche ► Geschichte / Ethik der Medizin
	Naturwissenschaften ► Biologie ► Biochemie
	Technik
Schlagworte	Biology • DNA • Protein • sequencing
ISBN-10	1-349-32122-2 / 1349321222
ISBN-13	978-1-349-32122-3 / 9781349321223
Zustand	Neuware