Organolithiums: Selectivity for Synthesis
Seiten
2002
Pergamon Press (Verlag)
978-0-08-043262-5 (ISBN)
Pergamon Press (Verlag)
978-0-08-043262-5 (ISBN)
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Whilst research into organolithium compounds has been ongoing, little is known about organolithium products of ortholithiation reactions. This volume contains an up-to-date survey of organolithiums and their use in synthesis.
This volume, number 23 in the "Tetrahedron Organic Chemistry" series, presents organolithium chemistry from the perspective of a synthetic organic chemist, drawing from the synthetic literature to present a unified overview of how organolithiums can be used to make molecules. The development of methods for the regioselective synthesis of organolithiums has replaced their image of indiscriminate high reactivity with one of controllable and subtle selectivity. Organolithium chemistry has a central role in the selective construction of C-C bonds in both simple and complex molecules, and for example has arguably overtaken aromatic electrophilic substitution as the most powerful method for regioselective functionalisation of aromatic rings. The twin themes of reactivity and selectivity run through the book, which reviews the ways by which organolithiums may be formed and the ways in which they react. Topics include advances in directed metallation, reductive lithiation and organolithium cyclisation reactions, along with a discussion of organolithium stereochemistry and the role played by ligands such as (-)-sparteine.
This volume, number 23 in the "Tetrahedron Organic Chemistry" series, presents organolithium chemistry from the perspective of a synthetic organic chemist, drawing from the synthetic literature to present a unified overview of how organolithiums can be used to make molecules. The development of methods for the regioselective synthesis of organolithiums has replaced their image of indiscriminate high reactivity with one of controllable and subtle selectivity. Organolithium chemistry has a central role in the selective construction of C-C bonds in both simple and complex molecules, and for example has arguably overtaken aromatic electrophilic substitution as the most powerful method for regioselective functionalisation of aromatic rings. The twin themes of reactivity and selectivity run through the book, which reviews the ways by which organolithiums may be formed and the ways in which they react. Topics include advances in directed metallation, reductive lithiation and organolithium cyclisation reactions, along with a discussion of organolithium stereochemistry and the role played by ligands such as (-)-sparteine.
Chapter 1: Introduction
Chapter 2: Regioselective Synthesis of Organolithiums by Deprotonation
Chapter 3: Regioselective Synthesis of Organolithiums by X-Li Exchange
Chapter 4: Regioselective Synthesis of Organolithiums by C–X Reduction
Chapter 5: Stereoselective and Stereospecific Synthesis of Organolithiums
Chapter 6: Stereoselective and Stereospecific Substitution Reactions of Organolithiums
Chapter 7: Regio- and Stereoselective Addition Reactions of Organolithiums
Chapter 8: Organolithium Rearrangements
Chapter 9: Organolithiums in Synthesis
Index
| Erscheint lt. Verlag | 12.7.2002 |
|---|---|
| Reihe/Serie | Tetrahedron Organic Chemistry |
| Verlagsort | London |
| Sprache | englisch |
| Maße | 152 x 229 mm |
| Gewicht | 1550 g |
| Themenwelt | Naturwissenschaften ► Chemie ► Organische Chemie |
| Naturwissenschaften ► Chemie ► Technische Chemie | |
| Technik | |
| ISBN-10 | 0-08-043262-X / 008043262X |
| ISBN-13 | 978-0-08-043262-5 / 9780080432625 |
| Zustand | Neuware |
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