Drug-Drug Interactions
Marcel Dekker Inc (Verlag)
978-0-8247-0283-0 (ISBN)
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This reference presents comprehensive coverage of the preclinical, clinical, toxicological, regulatory, and marketing perspectives of metabolism-based drug-drug interactions-relating pharmacokinetic concepts to Michaelis-Menten kinetics. The book provides helpful examples, representative enzyme systems, and computer-aided modeling to clarify key concepts. It offers nearly 200 useful tables, equations, drawings, and photographs, and contributions by world-renowned experts in the field. They discuss kinetics-based in vitro-in vivo correlations, methods for the development of a metabolic drug interaction (MDI) database, and more.
Introducing Pharmacokinetics and Pharmacodynamic Concepts, M. Rowland
In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes, K.R. Korzekwa
Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions, S.E. Clarke and B.C. Jones
Review of Human UDP-Glucuronosyltransferases and Their Role in Drug-Drug Interactions, R.P. Remmel
Drug-Drug Interactions Involving the Membrane Transport Process, H. Kusuhara and Y. Sugiyama
In Vitro Models for Studying Induction of Cytochrome P450 Enzymes, J.M. Silva and D.A. Nicoll-Griffith
In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs, A. Madan, E. Usuki, L.A. Burton, B.W. Ogilvie, and A. Parkinson
The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development, M.D. Troutman, G. Luo, L.-S. Gan, and D.R. Thakker
The Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions, K.E. Thummel and D.D. Shen
Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro-In Vivo Correlations, D.R. Jones and S.D. Hall
Prediction of Metabolic Drug Interactions: Quantitative or Qualitative? J.H. Lin and P.G. Pearson
In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans, G.R. Wilkinson
Molecular Modeling Approaches to Predict Drug Metabolism and Toxicity, A.M. ter Laak, M.J. de Groot, and N.P.E. Vermeulen
Development of a Metabolic Drug Interaction Database at the University of Washington, S.P. Carlson, I. Ragueneau-Majlessi, T.E. Bougan, and R.H. Levy
Drug-Drug Interactions: Clinical Perspective, D.J. Greenblatt and L.L. von Moltke
Drug-Drug Interactions: Toxicological Perspectives, S.D. Nelson
An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective, S.-M. Huang, P. Honig, L.J. Lesko, R. Temple, and R. Williams
Drug-Drug Interactions: Marketing Perspectives, K.J. Petty and J.M. Vega
Index
| Erscheint lt. Verlag | 19.10.2001 |
|---|---|
| Reihe/Serie | Drugs and the Pharmaceutical Sciences |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 152 x 229 mm |
| Gewicht | 1089 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Technik | |
| ISBN-10 | 0-8247-0283-2 / 0824702832 |
| ISBN-13 | 978-0-8247-0283-0 / 9780824702830 |
| Zustand | Neuware |
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