Biochemistry of Halogenated Organic Compounds

Kenneth L. Kirk (Autor)

Buch | Softcover

362 Seiten

2013 | Softcover reprint of the original 1st ed. 1991
Springer-Verlag New York Inc.
978-1-4757-4607-5 (ISBN)

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Biochemistry of Halogenated Organic Compounds has been written as a general reference source for researchers in several related areas, including organic chemists, medicinal chemists, pharmacologists, toxicologists, and medical researchers. The development of halogenated compounds as medicinal agents and pharmacological tools and the fascinating biochemi cal processes that have been discovered and studied using these analogues have generated extremely active areas of research and an enormous volume of literature. Thus, halogenated organic compounds pervade every aspect of biochemistry, a fact made apparent by the numerous reviews and monographs available on individual topics-halogenated nucleosides, halogenated carbohydrates, and so forth. Given the quantity of material already written on these topics, some of which material is quite current, it might be asked whether a one-volume review of these subjects is useful, or possible. Having now completed this work, I feel the answer to both questions is an emphatic yes. There are fascinating stories to be related in each area, and, where appropriate, I have attempted to develop these topics . from a historical perspective. For example, the discovery of the anticancer activity of fluorouracil, the unraveling of the several mechanisms of its action, and the development of a host of later generations of anticancer and antiviral agents based on the parent fluoro-, iodo-, bromo-, and trifluoromethylpyrimidines were, and are, contributions of major magnitude to medical science.

1. Biochemistry of Halogenated Carboxylic Acids.- 2. Biochemistry of Halogenated Aldehydes and Ketones.- 3. Biochemistry of Halogenated Analogues of Steroids, Isoprenyl Derivatives, and Other Terpenoids.- 4. Halogenated Analogues of Products of the Arachidonic Acid Cascade: Prostaglandins, Thromboxanes, and Leukotrienes.- 5. Biochemistry of Halogenated Nucleosides and Nucleotides.- 6. Biochemistry of Halogenated Carbohydrates.- 7. Biochemistry of Halogenated Amino Acids.- 8. Biochemistry of Halogenated Neuroactive Amines.

Reihe/Serie	Biochemistry of the Elements ; 9A+B
Zusatzinfo	XVII, 362 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
	Naturwissenschaften ► Chemie ► Physikalische Chemie
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	1-4757-4607-5 / 1475746075
ISBN-13	978-1-4757-4607-5 / 9781475746075
Zustand	Neuware