Diversity-Oriented Synthesis (eBook)

Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology

Andrea Trabocchi (Autor)

eBook Download: EPUB

2013 | 1. Auflage
664 Seiten
John Wiley & Sons (Verlag)
978-1-118-61814-1 (ISBN)

Infos

Discover an enhanced synthetic approach to developing and
screening chemical compound libraries

Diversity-oriented synthesis is a new paradigm for developing
large collections of structurally diverse small molecules as probes
to investigate biological pathways. This book presents the most
effective methods in diversity-oriented synthesis for creating
small molecule collections. It offers tested and proven strategies
for developing diversity-oriented synthetic libraries and screening
methods for identifying ligands. Lastly, it explores some promising
new applications based on diversity-oriented synthesis that have
the potential to dramatically advance studies in drug discovery and
chemical biology.

Diversity-Oriented Synthesis begins with an introductory
chapter that explores the basics, including a discussion of the
relationship between diversity-oriented synthesis and classic
combinatorial chemistry. Divided into four parts, the book:

* Offers key chemical methods for the generation of small
molecules using diversity-oriented principles, including
peptidomimetics and macrocycles

* Expands on the concept of diversity-oriented synthesis by
describing chemical libraries

* Provides modern approaches to screening diversity-oriented
synthetic libraries, including high-throughput and high-content
screening, small molecule microarrays, and smart screening
assays

* Presents the applications of diversity-oriented synthetic
libraries and small molecules in drug discovery and chemical
biology, reporting the results of key studies and forecasting the
role of diversity-oriented synthesis in future biomedical
research

This book has been written and edited by leading international
experts in organic synthesis and its applications. Their
contributions are based on a thorough review of the current
literature as well as their own firsthand experience developing
synthetic methods and applications.

Clearly written and extensively referenced,
Diversity-Oriented Synthesis introduces novices to this
highly promising field of research and serves as a springboard for
experts to advance their own research studies and develop new
applications.

Autor

ANDREA TRABOCCHI, PhD, is Assistant Professor of Organic Chemistry at the University of Florence. Dr. Trabocchi leads research in diversity-oriented synthesis, peptidomimetic chem-istry, chemical genetics, and conformational analysis.

Produkt-Details

• Erscheint lt. Verlag: 17.6.2013
• Vorwort: Stuart L. Schreiber
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• Schlagworte: Biochemie • biochemistry • Biowissenschaften • Chemie • Chemistry • Computational Chemistry & Molecular Modeling • Computational Chemistry u. Molecular Modeling • Life Sciences • Organic Chemistry • Organische Chemie
• ISBN-10: 1-118-61814-9 / 1118618149
• ISBN-13: 978-1-118-61814-1 / 9781118618141