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Genetic Influences on Addiction -

Genetic Influences on Addiction

An Intermediate Phenotype Approach
Buch | Hardcover
400 Seiten
2013
MIT Press (Verlag)
978-0-262-01969-9 (ISBN)
CHF 13,95 inkl. MwSt
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A comprehensive review of research examining intermediary mechanisms to understand the link between genetic variation and addiction liability.

Although there is scientific consensus that genetic factors play a substantial role in an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.

The contributors first consider the most established findings in the field, including variability in drug metabolism, brain electrophysiological profiles, and subjective reactions to direct drug effects; they go on to review highly promising areas such as expectancies, attentional processing, and behavioral economic variables; and finally, they investigate more exploratory approaches, including the differential susceptibility hypothesis and epigenetic modifications. Taken together, the chapters offer a macro-level testing of the hypothesis that these alternative, mechanistic phenotypes can advance the understanding of genetic influences on addiction. The book will be of interest to researchers and practitioners in a range of disciplines, including behavioral genetics, psychology, pharmacology, neuroscience, and sociology.

Contributors
John Acker, Steven R.H. Beach, Gene H. Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, Meg Gerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison, Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, Leah M. Mayo, Marcus R. Munafo, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker, Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E. Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet de Wit

James MacKillop is Associate Professor in the Department of Psychology at the University of Georgia, where he is also Associate Director of the William and Barbara Owens Institute for Behavioral Research, and Adjunct Associate Professor in the Department of Behavioral and Social Sciences at Brown University. Marcus R. Munafo is Professor of Biological Psychology at the University of Bristol, UK. James MacKillop is Associate Professor in the Department of Psychology at the University of Georgia, where he is also Associate Director of the William and Barbara Owens Institute for Behavioral Research, and Adjunct Associate Professor in the Department of Behavioral and Social Sciences at Brown University. Marcus R. Munafo is Professor of Biological Psychology at the University of Bristol, UK. Michael Windle is Professor of Public Health in the Department of Behavioral Sciences and Health Education at Emory University.

Reihe/Serie Genetic Influences on Addiction
Zusatzinfo 32 figures
Verlagsort Cambridge, Mass.
Sprache englisch
Maße 178 x 229 mm
Gewicht 780 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Suchtkrankheiten
Studium 2. Studienabschnitt (Klinik) Humangenetik
Technik Umwelttechnik / Biotechnologie
ISBN-10 0-262-01969-8 / 0262019698
ISBN-13 978-0-262-01969-9 / 9780262019699
Zustand Neuware
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