Mass Spectrometry for Drug Discovery and Drug Development (eBook)

Walter A. Korfmacher (Herausgeber)

eBook Download: PDF

2012 | 1. Auflage
476 Seiten
John Wiley & Sons (Verlag)
978-1-118-51612-6 (ISBN)

Infos

Facilitates the discovery and development of new, effective
therapeutics

With coverage of the latest mass spectrometry technology, this
book explains how mass spectrometry can be used to enhance almost
all phases of drug discovery and drug development, including new
and emerging applications. The book's fifteen chapters have been
written by leading pharmaceutical and analytical scientists. Their
contributions are based on a thorough review of the current
literature as well as their own experience developing new mass
spectrometry techniques to improve the ability to discover and
develop new and effective therapeutics.

Mass Spectrometry for Drug Discovery and Drug Development
begins with an overview of the types of mass spectrometers that
facilitate drug discovery and development. Next it covers:

* HPLC-high-resolution mass spectrometry for quantitative
assays

* Mass spectrometry for siRNA

* Quantitative analysis of peptides

* Mass spectrometry analysis of biological drugs

* Applications that support medicinal chemistry
investigations

* Mass spectrometry imaging and profiling

Throughout the book, detailed examples underscore the growing
role of mass spectrometry throughout the drug discovery and
development process. In addition, images of mass spectra are
provided to explain how results are interpreted. Extensive
references at the end of each chapter guide readers to the primary
literature in the field.

Mass Spectrometry for Drug Discovery and Drug Development
is recommended for readers in pharmaceutics, including medicinal
chemists, analytical chemists, and drug metabolism scientists. All
readers will discover how mass spectrometry can streamline and
advance new drug discovery and development efforts.

Autor

WALTER A. KORFMACHER, PhD, is Director of Bioanalysis at Genzyme, a Sanofi company, and Associate Editor at the Journal of Mass Spectrometry. Previously, he held positions at the FDA's National Center for Toxicological Research, Schering-Plough Research Institute, Merck Research Laboratories, and Medpace Bioanalytical Laboratories. Dr. Korfmacher is an international leader in developing mass spectrometry techniques and strategies for new drug discovery and drug metabolism applications. A 2009 recipient of the CPSA Distinguished Analytical Scientist Award, he has published more than 150 articles in the scientific literature and made more than eighty presentations at various scientific forums.

Inhalt

Contributors ix

Preface xi

1 Overview of the Various Types of Mass Spectrometers that are
Used in Drug Discovery and Drug Development 1

Gérard Hopfgartner

2 Utility of High-Resolution Mass Spectrometry for New Drug
Discovery Applications 37

William Bart Emary and Nanyan Rena Zhang

3 Quantitative Mass Spectrometry Considerations in a Regulated
Environment 55

Mohammed Jemal and Yuan-Qing Xia

4 Mass Spectrometry for Quantitative In Vitro ADME Assays
97

Jun Zhang and Wilson Z. Shou

5 Metabolite Identifi cation Using Mass Spectrometry in Drug
Development 115

Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash

6 MS Analysis of Biological Drugs, Proteins, and Peptides
149

Yi Du, John Mehl, and Pavlo Pristatsky

7 Characterization of Impurities and Degradation Products in
Small Molecule Pharmaceuticals and Biologics 191

Hui Wei, Guodong Chen, and Adrienne A. Tymiak

8 Liquid Extraction Surface Analysis (LESA): A New Mass
Spectrometry-Based Technique for Ambient Surface Profiling
221

Daniel Eikel and Jack D. Henion

9 MS Applications in Support of Medicinal Chemistry Sciences
239

Maarten Honing, Benno Ingelse, and Birendra N. Pramanik

10 Imaging Mass Spectrometry of Proteins and Peptides 277

Michelle L. Reyzer and Richard M. Caprioli

11 Imaging Mass Spectrometry for Drugs and Metabolites 303

Stacey R. Oppenheimer

12 Screening Reactive Metabolites: Role of Liquid
Chromatography-High-Resolution Mass Spectrometry in
Combination with "Intelligent" Data Mining Tools
339

Shuguang Ma and Swapan K. Chowdhury

13 Mass Spectrometry of siRNA 357

Mark T. Cancilla and W. Michael Flanagan

14 Mass Spectrometry for Metabolomics 387

Petia Shipkova and Michael D. Reily

15 Quantitative Analysis of Peptides with Mass Spectrometry:
Selected Reaction Monitoring or High-Resolution Full Scan?
403

Lieve Dillen and Filip Cuyckens

Index 427

Produkt-Details

• Erscheint lt. Verlag: 12.12.2012
• Reihe/Serie: Wiley-Interscience Series on Mass Spectrometry
• Reihe/Serie: Wiley-Interscience Series on Mass Spectrometry
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Analytische Chemie
• Themenwelt: Technik
• Schlagworte: Biowissenschaften • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Massenspektrometrie • Mass Spectrometry • Proteine u. Makromoleküle • Proteine u. Makromoleküle • Proteins & Macromolecules • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-51612-5 / 1118516125
• ISBN-13: 978-1-118-51612-6 / 9781118516126