Copper-Oxygen Chemistry (eBook)
480 Seiten
John Wiley & Sons (Verlag)
978-1-118-09434-1 (ISBN)
mediated by copper ions within biological systems
Copper-mediated biological oxidations offer a broad range of
fundamentally important and potentially practical chemical
processes that cross many chemical and pharmaceutical disciplines.
This newest volume in the Wiley Series on Reactive
Intermediates in Chemistry and Biology is divided into three
logical areas within the topic of copper/oxygen chemistry--
biological systems, theory, and bioinorganic models and
applications--to explore the biosphere for its highly evolved
and thus efficient oxidative transformations in the discovery of
new types of interactions between molecular oxygen and copper ion.
Featuring a diverse collection of subject matter unified in one
complete and comprehensive resource, Copper-Oxygen Chemistry probes
the fundamental aspects of copper coordination chemistry, synthetic
organic chemistry, and biological chemistry to reveal both the
biological and chemical aspects driving the current exciting
research efforts behind copper-oxygen chemistry. In addition,
Copper-Oxygen Chemistry:
* Addresses the significantly increasing literature on oxygen-atom
insertion and carbon-carbon bond-forming reactions as well as
enantioselective oxidation chemistries
* Progresses from biological systems to spectroscopy and theory,
and onward to bioinorganic models and applications
* Covers a wide array of reaction types such as insertion and
dehydrogenation reactions that utilize the cheap, abundant, and
energy-containing O2 molecule
With thorough coverage by prominent authors and researchers
shaping innovations in this growing field, this valuable reference
is essential reading for bioinorganic chemists, as well as organic,
synthetic, and pharmaceutical chemists in academia and
industry.
Kenneth D. Karlin is Ira Remsen Professor of Chemistry at Johns Hopkins University. His bioinorganic research focuses on coordination chemistry relevant to biological and environmental processes, involving copper or heme (porphyrin-iron) complexes. Dr. Karlin's main approach involves synthetic modeling, i.e., biomimetic chemistry. He is the winner of the prestigious F. Albert Cotton Award in Synthetic Inorganic Chemistry and the Sierra Nevada Distinguished Chemist Award, both awarded in 2009. Shinobu Itoh focuses his current research on chemical modeling and application of novel active sites in biological systems. He was formerly an assistant professor at Osaka University, where he worked on the chemistry of coenzyme PQQ and cofactor TTQ as well as model compounds of galactose oxidase. In 1994, he was promoted to associate professor at Osaka University, where he collaborated with Professor Shunichi Fukuzumi in copper-dioxygen chemistry research. In 1999, he moved to Osaka City University as a full professor and started biological studies of dinuclear copper proteins, such as hemocyanin and tyrosinase. He returned to Osaka University in 2008 and further expanded his research interests to the design of artificial non-heme metalloenzymes using genetic engineering.
Preface to Series vii
Introduction ix
Contributors xi
1 Insights into the Proposed Copper-Oxygen Intermediates
that Regulate the Mechanism of Reactions Catalyzed by Dopamine
b-Monooxygenase, Peptidylglycine a-Hydroxylating Monooxygenase, and
Tyramine b-Monooxygenase 1
Robert L. Osborne and Judith P. Klinman
2 Copper Dioxygenases 23
Jozsef Kaizer, Jozsef Sandor Pap, and Gabor Speier
3 Amine Oxidase and Galactose Oxidase 53
Dalia Rokhsana, Eric M. Shepard, Doreen E. Brown, and David M.
Dooley
4 Energy Conversion and Conservation by Cytochrome Oxidases
107
Angela Paulus and Simon de Vries
5 Multicopper Proteins 131
Takeshi Sakurai and Kunishige Kataoka
6 Structure and Reactivity of Copper-Oxygen Species
Revealed by Competitive Oxygen-18 Isotope Effects 169
Justine P. Roth
7 Theoretical Aspects of Dioxygen Activation in Dicopper Enzymes
197
Kazunari Yoshizawa
8 Chemical Reactivity of Copper Active-Oxygen Complexes
225
Shinobu Itoh
9 Cytochrome c Oxidase and Models 283
Zakaria Halime and Kenneth D. Karlin
10 Supramolecular Copper Dioxygen Chemistry 321
Jean-Noel Rebilly and Olivia Reinaud
11 Organic Synthetic Methods Using Copper Oxygen Chemistry
361
Marisa C. Kozlowski
Index 445
Erscheint lt. Verlag | 24.8.2011 |
---|---|
Reihe/Serie | Wiley Series of Reactive Intermediates | Wiley Series of Reactive Intermediates |
Sprache | englisch |
Themenwelt | Naturwissenschaften ► Biologie |
Naturwissenschaften ► Chemie ► Anorganische Chemie | |
Technik | |
Schlagworte | Bioanorganische Chemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • bioinorganic chemistry • Chemie • Chemistry • Organic Chemistry • Organische Chemie |
ISBN-10 | 1-118-09434-4 / 1118094344 |
ISBN-13 | 978-1-118-09434-1 / 9781118094341 |
Haben Sie eine Frage zum Produkt? |
Größe: 10,6 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich