Protein Kinase CK2 (eBook)

Lorenzo A. Pinna (Autor)

eBook Download: EPUB

2012 | 1. Auflage
480 Seiten
Wiley (Verlag)
978-1-118-48234-6 (ISBN)

Infos

Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

Autor

Lorenzo A. Pinna received his B. Sc. in Biochemistry from the University of Padova in 1962. From 1965-66 he was postdoctoral fellow at the Department of Physiological Chemistry, Johns Hopkins University Medical School, Baltimore, USA. In 1975 he was appointed Professor of Medical Chemistry and Biochemistry and in 1988 Director of the Department of Biological Chemistry at the University of Padova. A pioneer in the field of CK2 research, his research interests encompass various aspects of protein phosphorylation, with special reference to the design of synthetic peptide substrates for the specific monitoring of protein kinases and the assessment of the biological role and pathogenic potential of protein kinase CK2.

Inhalt

PART I: INTRODUCTION
1. "CK2, a protein kinase for all seasons" (Lorenzo A. Pinna Dept. Biological Chemistry, University of Padua, Padua, Italy.

PART II: MOLECULAR AND STRUCTURAL ASPECTS
2. "CK2 structures in the light of the spine concept of eukaryotic protein kinases " (Karsten Niefind, University of Cologne, Institute of Biochemistry, Cologne, Germany. E

3. "Structural bases for CK2 inhibition" (Roberto Battistutta, Department of Chemistry, University of Padua- Padova, Italy.

4. "The interactome of protein kinase CK2" (Mathias Montenarth, University of the Saarland, Medical Biochemistry and Molecular Biology, Homburg, Germany.

5. "The phosphoproteome generated by protein kinase CK2" (Mauro Salvi & Lorenzo A. Pinna Dept. Biological Chemistry, University of Padua, Padua, Italy.

PART III: FUNCTIONAL ASPECTS
6. "Intersection of CK2 with other signalling pathways" (David Litchfield, University of Western Ontario, Department of Biochemistry, London, Ontario, Canada.

7. "The role of protein kinase CK2 in the p53 response" (David W. Meek, University of Dundee, Biomedical Research Institute Ninewells Hospital, Dundee, UK.

8. "CK2 in embryonic development" (Isabel Dominguez, Boston University School of Medicine, Boston, MA, USA.

9. "Role of CK2 in the control of epithelial cell plasticity" (Claude Cochet, INSERM U873 iRTSV- CEA Grenoble, France.

10. "CK2 and circadian rhythm"

11. "The pivotal role of CK2 in chaperoning the kinome" (Yoshihiko Miyata, Kyoto University, Dept. Cell & Develop. Biology, Kyoto, Japan.

12. "CK2: a global regulator of cell survival" (Olaf-G. Issinger, University of Southern Denmark, Institute of Biochemistry and Molecular Biology, Odense, Denmark.

13. "Specific features of plant CK2" (Montserrat Pages, CSIC, CRAG, Barcelona, Spain.

PART IV: CK2 AND NEOPLASIA

14. "The oncogenic potential of CK2" (David C. Seldin, Boston University Medical Center, Department of Medicine, Boston MA, USA.

15. "CK2 suppression of apoptosis and its implication in cancer biology and therapy" (Khalil Ahmed, University of Minnesota and V.A. Medical Center, Minneapolis, MN, USA.

16. "Abnormal levels of CK2 and the generation of cancer "addiction" (Maria Ruzzene, Dept. Biological Chemistry, University of Padua, Padua, Italy.

17. "CK2 as an ideal target in cancer therapy: combining inhibitors of CK2 with various classes of chemotherapeutic agents" (Kenna Anderes, Cylene Pharmaceuticals, Cancer Biology, San Diego, CA, USA.

18. " CK2 in normal and malignant hematopoiesis" (Francesco Piazza, Venetian Institute of Molecular Medicine - VIMM, Padova, Italy.

Produkt-Details

• Erscheint lt. Verlag: 16.10.2012
• Reihe/Serie: The Wiley - IUBMB Series on Biochemistry and Molecular Biology
• Reihe/Serie: The Wiley - IUBMB Series on Biochemistry and Molecular Biology
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Biochemie • biochemistry • Biowissenschaften • Cell & Molecular Biology • Life Sciences • Proteine u. Makromoleküle • Proteine u. Makromoleküle • Proteinkinase • Proteins & Macromolecules • Zell- u. Molekularbiologie
• ISBN-10: 1-118-48234-4 / 1118482344
• ISBN-13: 978-1-118-48234-6 / 9781118482346