Protein Surface Recognition (eBook)

Approaches for Drug Discovery

Ernest Giralt, Mark Peczuh, Xavier Salvatella (Herausgeber)

eBook Download: EPUB

2011 | 1. Auflage
344 Seiten
John Wiley & Sons (Verlag)
978-1-119-95721-8 (ISBN)

Infos

A new perspective on the design of molecular therapeutics is
emerging. This new strategy emphasizes the rational complementation
of functionality along extended patches of a protein surface with
the aim of inhibiting protein/protein interactions. The successful
development of compounds able to inhibit these interactions offers
a unique chance to selectively intervene in a large number of key
cellular processes related to human disease.

Protein Surface Recognition presents a detailed treatment
of this strategy, with topics including:

* an extended survey of protein-protein interactions that are key
players in human disease and biology and the potential for
therapeutics derived from this new perspective

* the fundamental physical issues that surround protein-protein
interactions that must be considered when designing ligands for
protein surfaces

* examples of protein surface-small molecule interactions,
including treatments of protein-natural product interactions,
protein-interface peptides, and rational approaches to protein
surface recognition from model to biological systems

* a survey of techniques that will be integral to the discovery
of new small molecule protein surface binders, from high throughput
synthesis and screening techniques to in silico and in
vitro methods for the discovery of novel protein ligands.

Protein Surface Recognition provides an intellectual
"tool-kit" for investigators in medicinal and
bioorganic chemistry looking to exploit this emerging paradigm in
drug discovery.

Autor

ERNEST GIRALT, Department of Organic Chemistry, University of Barcelona and Institute for Research in Biomedicine, Barcelona, Spain MARK PECZUH, Department of Chemistry, University of Connecticut, USA XAVIER SALVATELLA, ICREA and Institute for Research in Biomedicine, Barcelona, Spain

Rezensionen

"This book picks up this trend and provides an excellent overview
of the current topics in the field of PPI modulation by small
molecules and peptides. . . Taken together, this excellent book is
very suitable both as an introduction to the field, as well as a
compendium for readers already familiar with the chemical approach
of modulating PPIs." (ChemMedChem, 2011)

Produkt-Details

• Erscheint lt. Verlag: 7.7.2011
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Life Sciences • Molekularbiologie • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie • Proteine • Wirkstoffforschung • Zell- u. Molekularbiologie
• ISBN-10: 1-119-95721-4 / 1119957214
• ISBN-13: 978-1-119-95721-8 / 9781119957218