Novel Therapeutic Proteins (eBook)

Selected Case Studies

Klaus Dembowsky, Peter Stadler (Herausgeber)

eBook Download: PDF

2008 | 1. Auflage
XXIV, 358 Seiten
Wiley-VCH (Verlag)
978-3-527-61303-8 (ISBN)

Infos

This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology.
Foreword written by Jürgen Drews.
Rekombinante, d.h. mit Hilfe von Gentechnik maßgeschneiderte Proteine finden immer mehr medizinische Anwendungen, und gentechnisch hergestellte Arzneimittel sind außerordentlich erfolgreich bei Krankheiten, die bislang sehr schwer bis gar nicht zu behandeln waren. Der Weltmarkt für therapeutische Proteine umfaßte 1998 17 Mrd. US$ - Tendenz deutlich steigend. Über 200 solcher Proteine befinden sich derzeit in Forschung und Entwicklung, und zahlreiche werden in den nächsten Jahren hinzukommen.
Mit einem Geleitwort von Jürgen Drews.
Das Buch gibt eine Übersicht über 15 der wichtigsten rekombinanten Proteine, die schon therapeutisch genutzt werden. Die Herausgeber und Autoren aus Pharma- und Biotech-Industrie sind aufs engste in die Forschung und Entwicklung rekombinanter Proteine eingebunden. Jedes Kapitel behandelt ein Protein mit klarem Fokus auf klinische Aspekte.

Inhalt

Foreword (Juergen Drews)
Preface (Klaus Dembowsky and Peter Stadler)
INTRODUCTION AND OVERVIEW
Medical Applications of Recombinant Proteins in Humans
Gayle Delmonte Wetzel
RECOMBINANT HORMONES
Clinical Applications of Recombinant Human Erythropoietin (Dimitrios Spentzos and Arthur J. Sytkowski)
Human Recombinant Growth Hormone (Carmen Ariznavarreta Ruiz and Jesús A.F. Tresguerres)
Human Recombinant Follicle Stimulating Hormone (Follitropin-a) (José A. Peinado, Colin M. Howles, and Jesús A.F. Tresguerres)
RECOMBINANT CYTOKINES AND THEIR RECEPTORS
Granulocyte Colony Stimulating Factor (G-CSF) (Karl Welte)
Interferon b-1b in Multiple Sclerosis (Bernd Aufdembrinke, Reinhard Horowski, and Joachim-Friedrich Kapp)
TNF-a -Receptors as Recombinant Proteins in Treatment of Rheumatoid Arthritis (Hanns-Martin Lorenz and Joachim R. Kalden)
RECOMBINANT ENZYMES, ENZYME ACTIVATORS AND INHIBITORS
Improvement of Principles of Nature: t-PA (Rolf G. Werner and Gerhard Heusel)
The Clinical Development of Recombinant Coagulation Factor VIII (KogenateÒ) for the Treatment of Hemophilia A (Peter J. Larson)
Aprotinin, Recombinant Aprotinin and Recombinant Aprotinin Mutants (Klaus Dembowsky and Werner Schroeder)
RECOMBINANT VACCINES
Recombinant Hepatitis B Vaccines -- Characterization of the Viral Disease and Vaccine Production in the Methylotrophic Yeast, Hansenula polymorpha (Stephan Schaefer, Michael Piontek, Sang-Jeom Ahn, Adam Papendieck, Zbigniew A. Janowicz and Gerd Gellissen)
MONOCLONAL ANTIBODIES
Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview (Mark Sopwith)
Antibody Therapy for Sepsis: Some Lessons Learned (Steven M. Opal)
An Engineered Human Antibody for Chronic Therapy: CDP571 (Mark Sopwith and Sue Stephens)
The Evolution of ReoPro(r) Clinical Development (Catherine F. Farrell, Elliot S. Barnathan and Harlan F. Weisman)
Index Foreword (Juergen Drews)
Preface (Klaus Dembowsky and Peter Stadler)
INTRODUCTION AND OVERVIEW
Medical Applications of Recombinant Proteins in Humans
Gayle Delmonte Wetzel
RECOMBINANT HORMONES
Clinical Applications of Recombinant Human Erythropoietin (Dimitrios Spentzos and Arthur J. Sytkowski)
Human Recombinant Growth Hormone (Carmen Ariznavarreta Ruiz and Jesús A.F. Tresguerres)
Human Recombinant Follicle Stimulating Hormone (Follitropin-a) (José A. Peinado, Colin M. Howles, and Jesús A.F. Tresguerres)
RECOMBINANT CYTOKINES AND THEIR RECEPTORS
Granulocyte Colony Stimulating Factor (G-CSF) (Karl Welte)
Interferon b-1b in Multiple Sclerosis (Bernd Aufdembrinke, Reinhard Horowski, and Joachim-Friedrich Kapp)
TNF-a -Receptors as Recombinant Proteins in Treatment of Rheumatoid Arthritis (Hanns-Martin Lorenz and Joachim R. Kalden)
RECOMBINANT ENZYMES, ENZYME ACTIVATORS AND INHIBITORS
Improvement of Principles of Nature: t-PA (Rolf G. Werner and Gerhard Heusel)
The Clinical Development of Recombinant Coagulation Factor VIII (KogenateÒ) for the Treatment of Hemophilia A (Peter J. Larson)
Aprotinin, Recombinant Aprotinin and Recombinant Aprotinin Mutants (Klaus Dembowsky and Werner Schroeder)
RECOMBINANT VACCINES
Recombinant Hepatitis B Vaccines -- Characterization of the Viral Disease and Vaccine Production in the Methylotrophic Yeast, Hansenula polymorpha (Stephan Schaefer, Michael Piontek, Sang-Jeom Ahn, Adam Papendieck, Zbigniew A. Janowicz and Gerd Gellissen)
MONOCLONAL ANTIBODIES
Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview (Mark Sopwith)
Antibody Therapy for Sepsis: Some Lessons Learned (Steven M. Opal)
An Engineered Human Antibody for Chronic Therapy: CDP571 (Mark Sopwith and Sue Stephens)
The Evolution of ReoPro(r) Clinical Development (Catherine F. Farrell, Elliot S. Barnathan and Harlan F. Weisman)
Index

Produkt-Details

• Erscheint lt. Verlag: 11.7.2008
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Biotechnologie • Biotechnologie i. d. Biowissenschaften • Biotechnology • Biowissenschaften • Cell & Molecular Biology • Chemie / Organische Chemie • Genetics • Genetik • Life Sciences • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Rekombinantes Protein • Zell- u. Molekularbiologie
• ISBN-10: 3-527-61303-X / 352761303X
• ISBN-13: 978-3-527-61303-8 / 9783527613038