Pharmaceutical Biotechnology (eBook)

Drug Discovery and Clinical Applications

Oliver Kayser, Rainer H. Müller (Herausgeber)

eBook Download: PDF

2006 | 1. Auflage
XXV, 311 Seiten
Wiley-VCH (Verlag)
978-3-527-60552-1 (ISBN)

Infos

With its focus on industrial pharmaceutical research, written by international experts from the industry, this book fills in a gap in the existing literature. It reflects the combination of such pharmaceutical interests as drug delivery, drug targeting, quality and safety management, drug approval and regulation, patenting issues and biotechnology fundamentals.
Thus it provides practitioners in pharmaceutical biotechnology with all the relevant information from the shelf.
The first part offers a comprehensive survey and review of the rapidly increasing array of biopharmaceuticals derived from the molecular biological approaches now widely available. This is followed by an extra section devoted to the very critical patenting and drug regulation issues. The whole is rounded off by detailed monographs of biotechnologically developed drugs that are already on the market.

With a foreword of by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at the Massachusetts Institute of Technology. In 2002, he received the Charles Stark Draper Prize, the highest recognition for an engineer. Professor Langer is member of all three national academies - the Institute of Medicine, the National Academy of Engineering, and the National Academy of Sciences:
"The book attempts to provide a balanced view of the biotechnological industry and the number of experts from industry sharing their knowledge and experience with the audience gives the book an outstanding value. All contributors provide with each chapter an up-to-date review on key topics in pharmaceutical biotechnology.
This work is not only a valuable tool for the industrial expert but also for all pharmacists and scientists from related areas who wish to work with biotech drugs."
Pharmaceutical Biotechnology wurde von einem internationalen Expertenteam aus der Industrie verfasst. Mit seinem starken Praxisbezug schließt es eine Lücke in der Literatur zu diesem Gebiet. Der Band reflektiert das Zusammenspiel verschiedener pharmazeutischer Themen wie z.B. gezielte Pharmakotherapie (also die Wirkstofffreisetzung am Zielort), Qualitäts- und Sicherheitsmanagement, Medikamentenzulassung und -regulierung, Patentfragen sowie die Grundlagen der Biotechnologie.

Das Buch behandelt alle Themen und Technologien, die beim industriellen Prozess der Entwicklung, Charakterisierung, Produktion und Registrierung pharmazeutischer Biotechnologie-Produkte eine Rolle spielen. Damit ist es das ideale Nachschlagewerk für Praktiker in der pharmazeutischen Biotechnologie, die schnellen Zugriff auf alle relevanten Informationen suchen.
Der erste Teil dient als Einführung und stellt Konzepte und Technologien der pharmazeutischen Biotechnologie vor. Er bietet einen umfassenden Überblick über die rapide wachsende Zahl von Biopharmazeutika, die auf molekularbiologischen Methoden beruhen und mittlerweile breit eingesetzt werden. Im Abschnitt "Industrielle Entwicklung und der Produktionsprozess" geht es unter anderem um wissenschaftliche, technische und ökonomische Aspekte der Impfstoffforschung und -entwicklung (z. B. um DNA-Vakzine). Es folgen Ausführungen zur Charakterisierung und zu bioanalytischen Aspekten rekombinanter Proteine als pharmazeutische Medikamente sowie zu biogenerischen Wirkstoffen. Ein eigener Abschnitt widmet sich den schwierigen patentrechtlichen Problemen. "Biotech 21" schließlich stellt die Perspektiven der pharmazeutischen Biotechnologie vor, etwa die somatische Gentherapie oder die Xenotransplantation. Abgerundet wird das Werk durch einen ausführlichen Index.

Autor

Oliver Kayser: Oliver Kayser received his PhD at the Free University Berlin in 1997 following his fellowship at the University of Gainesville, Florida, whereupon he entered the pharmaceutical biotechnology industry. He is currently a lecturer at the Department of Pharmaceutics, Biopharmacy and Biotechnology at the FU Berlin, working on new biotech drugs from natural sources and on the development of drug delivery carriers based on nanosuspension and solid lipid nanoparticle enterprise technologies. Rainer H. Müller: Professor Müller is Head of the Department of Pharmaceutical Technology, Biotechnology & Quality Management at the Free University Berlin. His research focuses on solid lipid nanoparticles, nanosuspensions of poorly soluble drugs and drug targeting using the concept of "differential protein adsorption". He obtained his PhD at Kiel University in 1983, and spent 4 years as visiting scientist at the Pharmacy Department, University of Nottingham, UK and 1 year at the Université de Paris-Sud.

Inhalt

PART 1. INTRODUCTION TO CONCEPTS AND TECHNOLOGIES IN PHARMACEUTICAL BIOTECHNOLOGY
A Primer on Pharmaceutical Biotechnology and Industrial Applications (Kayser, Müller)
Procaryotic and Eucaryotic Cells in Biotech Production (Bechthold)
Biopharmaceuticals Expressed in Plants (Knäblein)
PART 2. INDUSTRIAL DEVELOPMENT AND PRODUCTION PROCESS
Scientific, Technical and Economic Aspects of Vaccine Research and Development (Gregersen)
DNA Vaccines: From Research Tools in Mice to Vaccines in Humans (Ulmer)
Characterisation and Bioanalytical Aspects of Recombinant Proteins as Pharmaceutical Drugs (Haunschild)
Biogeneric Drugs (Hinderer)
PART 3. THERAPEUTIC PROTEINS - SPECIAL PHARMACEUTICAL ASPECTS
Pharmacokinetics and Pharmacodynamics of Biotech Drugs (Meibohm)
Formulation of Biotech Drugs (Lipp)
Patents in Biotechnology Industry: Legal and Ethical Issues (Resnick)
Drug Approval in the EU und US (Walsh)
PART 4. BIOTECH 21 - INTO THE NEXT DECADE
Rituximab (Grillo)
Somatic Gene Therapy (Gottschalk)
Non Viral Gene Delivery Systems (Kayser)
Xenotransplantation in Pharmaceutical Biotechnology (Brunn)
Sculpturing the Architecture of Mineralized Tissues: Tissue Engineering of Bone from Soluble Signals to Smart Biomimetic Matrices (Ripamonti)
INDEX

Rezensionen

"This textbook provides a concise overview of pharmaceutical biotechnology focusing on the industrial needs of recombinant drugs, processes, and clinical use."
E-STREAMS

"... international experts ... have provided precise and valuable information for the industrial experts, scientists, pharmacists, research managers..."
American Journal of Therapeutics

Produkt-Details

• Erscheint lt. Verlag: 6.3.2006
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biotechnologie • Biotechnologie i. d. Biowissenschaften • Biotechnology • Biowissenschaften • Chemie • Chemistry • Industrial Chemistry • Life Sciences • Medical Science • Medizin • Pharmaceutical & Medicinal Chemistry • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Pharmazeutische Technologie • Pharmazeutische u. Medizinische Chemie • Technische u. Industrielle Chemie
• ISBN-10: 3-527-60552-5 / 3527605525
• ISBN-13: 978-3-527-60552-1 / 9783527605521