Protein-Lipid Interactions (eBook)

From Membrane Domains to Cellular Networks

Lukas K. Tamm (Herausgeber)

eBook Download: PDF

2006 | 1. Auflage
XXVI, 444 Seiten
Wiley-VCH (Verlag)
978-3-527-60699-3 (ISBN)

Infos

In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

Autor

Lukas Tamm studied Molecular Biology and Biophysics at the University of Basel (Switzerland) and at Cornell University. After obtaining his PhD in Biophysics from the University of Basel in 1982, he moved to Stanford University for postdoctoral work with H. M. McConnell. Returning to Basel, he was appointed as a junior faculty member before joining thefaculty of the University of Virgina in 1990. He currently holds a chair in Molecular Physiology and Biological Physics and served as director of heinterdisciplinary program in biophysics at the University of Virginia from 1999-2003.

Inhalt

HOW LIPIDS SHAPE PROTEINS
Lipid Bilayers, Translocons, and the Shaping of Polypeptide Structure
Folding and Stability of Monomeric beta-Barrel Membrane Proteins
Principles, Kinetics and Stability of Bacteriorhodopsin Folding
Post-Integration Misassembly of Membrane Proteins and Disease

HOW PROTEINS SHAPE LIPIDS
A Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane Proteins
Lipid and Detergent Interactions with Membrane Proteins Derived from Solution NMR

MEMBRANE PENETRATION BY TOXINS
Lipid Interactions of alpha-Helical Protein Toxins
Membrane Recognition and Pore Formation by Bacterial Pore-forming Toxins
Mechanism of Membrane Permeation and Pore Formation by Antimicrobial Peptides

MECHANISMS OF MEMBRANE FUSION
Cell Fusion in Development and Disease
Molecular Mechanisms of Intracellular Membrane Fusion
Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion

CHOLESTEROL, LIPID RAFTS, AND PROTEIN SORTING
Protein-Lipid Interactions in the Formation of Raft Microdomains
Protein and Lipid Partitioning in Locally Heterogeneous Model Membranes

TARGETING OF EXTRINSIC MEMBRANE PROTEIN MODULES TO MEMBRANES AND SIGNAL TRANSDUCTION
In vitro and Cellular Membrane Binding Mechanisms of Membrane Targeting Domains
Structure and Interactions of C2 Domains at Membrane Surfaces
Structural Mechanisms of Allosteric Regulation by Membrane-binding domains

Rezensionen

"...for the advanced student, researcher, or teacher of life sciences, it can be highly recommended."
ChemBioChem

"Considered as a whole, this is an excellent collection of highly topical articles in the field of lipid-protein interactions. Every article contains a comprehensive and up-to-date list of references, giving the reader access to a wealth of primary literature. An especially valuable resource is the compilation of current data relating to the individual topics that have been extracted from protein data banks; these also provide a good basis for planning further work. The keyword index enables the reader to find relevant discussions in the various articles. The book is a worthwhile addition to the private collections of all those who are concerned with lipid-protein interactions."
Angewandte Chemie

"The book is very useful reading, well-organized and carefully written by well-renowned authorities in their fields, and can be most warmly recommended both for students as well as specialized scientists."
European Journal of Lipid Science and Technology

"Numerous figures throughout this volume provide excellent illustrative material to support the detailed information presented in the text. In conclusion, this comprehensive volume is highly recommended to all the persons working in this exciting area."
Carbohydrate Polymers

"Dieses Buch ist geeignet für die wissenschaftliche Leserschaft in Biologie und Medizin."
Umwelt & Gesundheit

"Insgesamt handelt es sich um eine rundum gelungene Zusammenstellung von Beiträgen über Lipid-Protein-Wechselwirkungen. Alle Beiträge verfügen über eine umfangreiche und aktuelle Literaturliste, besonders hervorzuheben ist auch, dass Daten aus Proteindatenbanken erhoben wurden, die eine gute Diskussionsgrundlage für weitere Arbeiten liefern. Für Forscher, die sich mit Lipid-Protein-Wechselwirkungen beschäftigen, ist das Buch auf jeden Fall eine Bereicherung."
Angewandte Chemie

Produkt-Details

• Erscheint lt. Verlag: 12.5.2006
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• Schlagworte: Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biophysics • Biophysik • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Life Sciences • Mikrobiologie • Molekularbiologie • Neuroscience • Neurowissenschaften • Physics • Physik • Zell- u. Molekularbiologie
• ISBN-10: 3-527-60699-8 / 3527606998
• ISBN-13: 978-3-527-60699-3 / 9783527606993