Proteomic and Genomic Analysis of Cardiovascular Disease (eBook)

Jennifer E. Van Eyk, Michael J. Dunn (Herausgeber)

eBook Download: PDF

2006 | 1. Auflage
XXVII, 396 Seiten
Wiley-VCH (Verlag)
978-3-527-60545-3 (ISBN)

Infos

This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world.
Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area. Herz-Kreislauferkrankungen sind die Zivilisationskrankheit Nummer 1. Dies ist weltweit das erste Buch, das sich mit der Analyse des Proteoms und Genoms von betroffenen Patienten beschäftigt. Diese neuen Forschungsansätze haben bereits erste erstaunliche Ergebnisse erzielt. Man erwartet neue Einblicke in die biochemischen und zellulären Grundlagen der Krankheitsentstehung und außerdem interessante Hinweise auf die Entwicklung von neuen Diagnostica und Therapeutica. Gegliedert in zwei Teile werden die Möglichkeiten, aber auch die Grenzen dieser neuen Analysetechniken aufgezeigt. Es werden verschiedene Arbeitsstrategien und die entsprechenden methodischen Arbeitsschritte vorgestellt. Klinische Anwendungsmöglichkeiten werden dabei ebenfalls berücksichtigt. Das Werk richtet sich an Molekularbiologen, Biochemiker und Chemiker in der Grundlagenforschung und der chemisch-pharmazeutischen Industrie, insbesondere in der Arzneimittelforschung.

Inhalt

GENOMICS
Large scale expression profiling in cardiovascular disease using microarrays: prospects and pitfalls
Global Genomic Analyses of Cardiovascular Disease: A Potential Map or Blind Alley?
Heart Failure: A Genomics Perspective
Experimental application of the genomic microarray analysis of both human and animal models of heart failure
Gene Profiling in the Heart by Subtractive Hybridization
DNA Mircoarray Gene Profiling: A Tool for the Elucidation of Cardioprotective Genes
Pitfalls Associated With cDNA Microarrays; A Cautionary Tale
Application of Biologic Skepticism to Analysis of Expression Phenotypes
Genes involved in atherosclerosis and plaque formation
PROTEOMICS
Proteomics of the Cardiovascular Disease - A Step Beyond Genomics
Mass spectrometry - A Powerful Analytical Tool
Differential Expression Proteomic Analysis Using Isotope Coded Affinity Tags
Protein chip technology in proteomics analysis
Recent Applications of Functional Proteomics: investigations in smooth muscle cell physiology
Gene Expression Profiling in Pulmonary and Systemic Vascular Cells Exposed to Biomechanical Stimuli
Identification of Targets of Phosphorylation in Heart Mitochondria
Proteomic Characterization of Protein Kinase C Signaling Tasks in the Heart
Identification of Secreted Oxidative Stress-Induced Factors (SOXF) and Associated Proteins: Proteomics in Vascular Biology
Myofilament proteomics: understanding contractile dysfunction in cardiorespiratory disease
FUTURE PERSPECTIVES
Genomics Perspective for Drug Discovery
Proteomics: A Post-Genomic Platform for Drug Discovery and Development

Rezensionen

"...this is a highly recommended book..."
Human Genomics

"...provides a timely integration of the emerging technologies of genomics, proteomics and drug discovery...suitable for all levels..."
Briefings in Functional Genomics and Proteomics, Vol 2(4), Feb 2004

"This is a very good book, whose best virtue is that it reliably reflects the current status of genomics and proteomics in the cardiovascular area. The inclusion of both fields in the same book could be considered excessively ambitious, but the result is very positive....
Overall, this is a highly recommended book, written by specialists in their fields, offering a clear and concise overview of the basis for, and latest developments in, cardiovascular genomics and proteomics."

Fernando Vivanco, Fundación Jímenez Díaz, Madrid, Spain
Human Genomics 1/04

"In summary, this book provides a strong foundation in genomic and proteomic methodology and will bring the reader to the forefront in the use of these tools in cardiovascular disease research."
Alan T. Remaley
Clinical Chemistry

Produkt-Details

• Erscheint lt. Verlag: 6.3.2006
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Genom • Herz-Kreislauf-System • Life Sciences • Medical Science • Medizin • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie • Proteomanalyse • Zell- u. Molekularbiologie
• ISBN-10: 3-527-60545-2 / 3527605452
• ISBN-13: 978-3-527-60545-3 / 9783527605453