Protein Microarray Technology (eBook)

Dev Kambhampati (Herausgeber)

eBook Download: PDF

2006 | 1. Auflage
XXXII, 244 Seiten
Wiley-VCH (Verlag)
978-3-527-60521-7 (ISBN)

Infos

This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins.
The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions.

Topics covered include:
-Types of biomolecular interactions
-Surface chemistry
-Detection technologies
-Spotting technologies
-Bioinformatics/data analysis.

While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security.
Aus der Wirkstoffforschung im Post-Genom-Zeitalter sind Protein-Mikroarray-Verfahren mit Sicherheit bald nicht mehr wegzudenken. Alle bereits jetzt am Markt befindlichen "Protein-Chips" mit ihren Vor- und Nachteilen werden in diesem für Forscher aus der Wirkstoff- und Pharmaindustrie gedachten Buch diskutiert. Sehr aktuell angesichts des prognostizierten lawinenartigen Wachstums des Protein-Chip-Marktes!

Inhalt

Introduction: From Fundamental Screening to Clinical Diagnostics
Surface Plasmon Fluorescence Spectroscopy for Protein Binding Studies
SPR Imaging Measurements of Protein Interactions to DNA and Peptide Arrays on Gold Thin Films
Seeing beneath the surface of biomolecular interactions Real-time characterization of label-free binding interactions using Biacore's optical biosensors (Biacore)
Optimization of a Protein Microarray Platform Based on a Small-molecule Chemical Affinity System (Prolinx)
Protein Microarray Surface Chemistry and Coupling Schemes (Xomics)
The use of ProteinChip Arrays in deciphering Biological Pathways (Ciphergen)
Image Analysis Issues and Solutions for High-Density Arrays (Biodiscovery)
Nanomechanical cantilever sensors for miroarrays
Production of Protein Microarrays (Genetix)

Rezensionen

"...most useful for those who want to get into the field and need a thorough briefing..."
Chemistry World

"I can recommend this book as a most helpful reference for students and researchers, particularly for those who are interested in detection technologies for protein microarrays and other fields of bioanalytic science."
Advanced Materials

"Overall, this text fills a gap in the literature. By presenting the combined knowledge of 24 leading experts, it certainly lowers the activation barrier that the novice has to overcome to enter the field. It also provides a good source for new ideas upon careful reading. Therefore, I can recommend the book for students and researchers planning to use protein microarrays, and to specialists seeking new methods of detection."
Angewandte Chemie

"Insgesamt füllt dieses Buch eine bisherige Lücke in der bioanalytischen Literatur und erweist sich außerdem als gute Quelle für neue Ideen. Empfehlen kann ich es insbesondere Studenten und Wissenschaftlern, die sich der Forschung mit Protein-Mikroarrays zuwenden wollen, aber auch Spezialisten, die nach neuen Detektionsmöglichkeiten suchen."
Angewandte Chemie

Produkt-Details

• Erscheint lt. Verlag: 6.3.2006
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Analytical Chemistry • Analytische Chemie • Arzneimittelforschung • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biochip • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Life Sciences • Zell- u. Molekularbiologie
• ISBN-10: 3-527-60521-5 / 3527605215
• ISBN-13: 978-3-527-60521-7 / 9783527605217