Centrosomes in Development and Disease (eBook)

Erich A. Nigg (Herausgeber)

eBook Download: PDF

2006 | 1. Auflage
XLII, 432 Seiten
Wiley-VCH (Verlag)
978-3-527-60434-0 (ISBN)

Infos

Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this organelle in a broader scientific community.

The centrosome controls the number and distribution of microtubules - a major element of the cell cytoskeleton - and hence influences many important cellular functions and properties. These include cell shape, polarity, and motility, as well as the intracellular transport and positioning of various organelles. Of particular interest, centrosome function is critical for chromosome segregation and cell division.

This book is meant to summarize our current knowledge of the structure, function and evolution of microtubule organizing centers, primarily centrosomes. Emphasis is on the role of these organelles in development and disease (particularly cancer). Das vor über einem Jahrhundert entdeckte Zentrosom ist das wichtigste Mikrotubuli-Organisationszentrum (MTOC) tierischer Zellen. Im Laufe der vergangenen Jahre ergaben intensive Forschungsarbeiten, dass sich Anomalien dieser Organellen in den meisten menschlichen Tumoren finden. Dieses hochaktuelle Buch fasst den gegenwärtigen Kenntnisstand zu Struktur, Aufbau und Funktion der Zentrosome sowie zu ihrer Bedeutung bei der Entwicklung bestimmter Krankheitsbilder zusammen und wird ein breites Leserspektrum - vom Zell- und Molekularbiologen bis zum Onkologen - interessieren.

Autor

Erich Nigg obtained his PhD in Biochemistry from the Swiss Federal Institute of Technology (ETH) in Zurich. After postdoctoral training in California, he directed research groups at the ETH and the Swiss Institute for Experimental Cancer Research, before being appointed Full Professor at the University of Geneva. In 1997, he became Director and Scientific Member of the Max-Planck Society, and has been head of the Cell Biology Department at the Max-Planck Institute for Biochemistry in Martinsried/Munich since October 1999. Professor Nigg's research interests are centered on cell cycle control, with a current focus on the regulation of the centrosome cycle, cell division, and the problem of chromosomal instability in cancer.

Inhalt

Early Studies on Centrioles and Centrosomes (J. Gall)
MICROTUBULE ORGANIZATION AND DYNAMICS
The tubulin superfamily (T. Stearns)
Microtubule nucleation (M. Moritz)
The Budding Yeast Spindle Pole Body: A Centrosome Analog (M. Winey)
Dissection of basal body and centriole function in the unicellular green alga Chlamydomonas reinhardtii (S. Dutcher)
The Centrosome in evolution (M. Bornens)
THE INTEGRATION OF CENTROSOME AND CHROMOSOME CYCLES
A Proteomic approach to the inventory of the human centrosome (C. Wilkinson)
The Role of the Centrosome in Cell Cycle progression (A. Fry)
Centrosome duplication and its regulation in the higher animal cell (G. Sluder)
A Synergy of Technologies: Using Green Fluorescent Protein Tagging and Laser Microsurgery to Study Centrosome Function and Duplication in Vertebrates (A. Khodjakov)
Centrosome regulation in response to environmental and genotoxic stress (W. Theurkauf)
THE CENTROSOME IN DEVELOPMENT AND TISSUE ARCHITECTURE
The C. elegans centrosome during early embryonic development (A. Hyman)
Centrosome in a developing organism: lessons from Drosophila (J. Raff)
Centrosome inheritance during fertilization and cloning: implications for stem cell medicine and human reproduction (G. Schatten)
Microtubule Organising Centres in Polarised Epithelial Cells (M. Mogensen)
MICROTUBULE ORGANIZING CENTERS IN DISEASE
Centrosome anomalies in cancer: from early observations to animal models (B. Brinkley)
Radiation-therapy and centrosome anomalies in pancreatic cancers (N. Sato)
Human papillomavirus infection and centrosome anomalies in cervical cancer (K. Münger)
Interactions between centrosomes and viral and bacterial pathogens (M. Way)
Basal bodies and microtubule organization in pathogenic protozoa (K. Gull)

Rezensionen

"Nonetheless, the book is well written and provides clear, concise and informative reviews of key topics. Both experts and novices alike will find this book to be an indispensable source of information on an organelle that is becoming less mysterious but more fascinating."
Nature Cell Biology

"... a comprehensive book which is well written, concise and has many excellent reviews of the key topics in the field. The book balances the historical with the cutting edge, the background with the detail and is therefore a recommended read for the newcomer and the experienced centrosome researcher alike."
The Newsletter of the British Society of Cell Biology

"... will serve as a rich source of information for a wide audience ... a valuable contribution to the literature."
Doody's Health Services

"...a specialty text in the finest sense of the Wiley applied science list."
Electric Review

"The chapters are well written, understandable, and provide clear explanations of difficult concept...highly recommended for academic and special libraries with related research areas."
E-STREAMS

Produkt-Details

• Erscheint lt. Verlag: 24.1.2006
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biomedizin • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Life Sciences • Medical Science • Medizin • Molekularbiologie • Oncology & Radiotherapy • Onkologie • Onkologie u. Strahlentherapie • Zell- u. Molekularbiologie
• ISBN-10: 3-527-60434-0 / 3527604340
• ISBN-13: 978-3-527-60434-0 / 9783527604340