Burger's Medicinal Chemistry and Drug Discovery
John Wiley & Sons Inc (Verlag)
978-0-471-37032-1 (ISBN)
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This new sixth edition of "Burger's Medicinal Chemistry and Drug Discovery" offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.With expanded content from 69 chapters to over 100 chapters, this sixth edition of "Burger's Medicinal Chemistry and Drug Discovery" includes more than 50 percent new material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science, including: proteomics; genomics; bioinformatics; combinatorial chemistry; high-throughput screening; blood substitutes; allosteric effectors as potential drugs; COX inhibitors; statins; high-throughput pharmacology and more.The new sixth edition of "Burger's Medicinal Chemistry and Drug Discovery" is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951.
Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.
VOLUME 1 Structure Based Drug-Design History of Quantitative Structure Activity Relationships Recent and Developing Trends in QSAR: From Data Analysis and Model Validation to Drug Design and Discovery Molecular Modeling in Drug Design Drug-Target Binding Forces: Advances in Force Field Approaches Combinatorial Library Design, Molecular Similarity and Diversity Applications Virtual Screening Docking and Scoring Functions/Virtual Screening Bioinformatics Chemical Information Computing Systems in Drug Discovery X-ray Crystallography Drug Discovery Electron Microscopy of Biological Macromolecules Design of Peptidomimetics Approaches to the Rational Design of Enzyme Inhibitors Chirality and Biological Activity Structural Concepts in the Prediction of the Toxicity of Therapeutical Agents Natural Products as Leads for New Pharmaceuticals Analog Design NMR and Drug Discovery Mass Spectrometry and Drug Design VOLUME 2 Combinatorial Chemistry and Multiple Parallel Synthesis Highthroughput Screening for Lead Discovery High Throughput Pharmacology The Application of Recombinant DNA Technology in Medicinal Chemistry and Drug Discovery Oligonucleotide Therapeutics Therapeutic Agents Acting on RNA Carbohydrate Based Therapeutics Membrane Transport Proteins and Drug Transport Allosteric Proteins and Drug Discovery Receptor Targets in Drug Discovery and Development Large Scale Synthesis Principles of Drug Metabolism Metabolic Considerations in Prodrug Design Retrometabolism-Based Drug Design and Targeting Drug Discovery: The Role of Toxicology Drug Absorption, Distribution, and Elimination The FDA and Regulatory Issues Intellectual Property in Drug Discovery and Biotechnology Nicotinic Acetylcholine Receptors Physicochemical Characterization and Principles of Oral Dosage Form Selection VOLUME 3 Cardiac Drugs: Antianginal, Vosodilators, Antiarrhythmic Diuretics and Uricosuric Agents Myocardial Infarction Agents Endogenous Vasoactive Peptides Hematopoietic Agents Anticoagulatns, Antithrombotics and Hemostatics Antihyperlipedemic Agents Oxygen Delivery via Allosteric Effectors of Hemoglobin, Blood Substitutes, and Plasma Expanders Sickle Cell Anemia Iron Chelators and Therapeutic Uses Thyroid Hormones and Thyromimetics Male Sex Hormones, Analogs, and Antogonists Anti-inflammatory Steroids Female Sex Hormones, Contraceptives & Fertility Drugs Fundamentals of Steroid Chemistry and Biochemistry VOLUME 4 Peptide and Protein Hormones, Peptide Neurotransmitters, and Therapeutic Agents Inhibitors of Gastric Acid Secretion Chemokines and Cytokine Modulators COX Inhibitors and Leukotriene Modulators Agents Acting on Prostanoid Receptors Retinoids Vitamins Life Style and Over-the-Counter Agents Radiopaques Microarrays and Gene Expression Profiling Applied to Drug Research SNPs: Single Nucleotide Polymorphisms and Pharmacogenomics Gene Therapy with Plasmid DNA Insulin and Hypoglycemic Agents VOLUME 5 Molecular Biology of Cancer Synthetic DNA-targeted Chemotherapeutic Agents and Related Tumor-Activated Prodrugs Antitumor Natural Products Radiosensitizers and Radioprotective Agents Synthetic Anti-angiogenic Agents Future Strategies in Immunotherapy Selective Toxicities Drug Resistance in Cancer Chemotherapy Antiviral Agents, DNA Antiviral Agents, RNA (Viruses other than HIV), Orthopoxviruses Rationale of Design of Anti-HIV Drugs Organ Transplantation Drugs Synthetic Antibacterial Agents Lactam Antibiotics Tetracyclines, Aminolycoside, Macrolide, and Miscellaneous Antibiotics Antimycobacterial Agents Antifungal Agents Antimalarial Agents Antiprotozoal Agents Anthelmintic Agents VOLUME 6 Andrenergics and Andrenergic Blocking Agents Cholinergics Anticholinergic Drugs CNS Stimulants Sedatives and Hypnotics Anticonvulsants Analgesics Antidepressants Antianxiety Agents Antipsychotic Agents Investigative Agents for use in Neurodegenerative Conditions Therapeutic and Diagnostic Agents for Parkinson's Disease Alzheimer's Disease: Search for Therapeutics Cognition Enhancers Drugs to Treat Eating and Body Weight Disorders
| Erscheint lt. Verlag | 25.3.2003 |
|---|---|
| Zusatzinfo | Illustrations (some col.), 1 port. |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 184 x 261 mm |
| Gewicht | 9965 g |
| Einbandart | gebunden |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Naturwissenschaften ► Chemie | |
| Technik | |
| ISBN-10 | 0-471-37032-0 / 0471370320 |
| ISBN-13 | 978-0-471-37032-1 / 9780471370321 |
| Zustand | Neuware |
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