Mims' Pathogenesis of Infectious Disease (eBook)

Cedric A. Mims, Anthony A. Nash, John Stephen (Autoren)

eBook Download: PDF

2000 | 5. Auflage
464 Seiten
Elsevier Science (Verlag)
978-0-08-053850-1 (ISBN)

Infos

Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.

Key features and of the 5th edition include:
* Microbial gene sequencing
* Up-to-date picture of the global burden of infectious diseases
* Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence
* Latest data on combination vaccines, the promise of edible vaccines
* The spread of antibiotic resistance genes among bacteria
* HIV1 and HIV2, molecular biology, pathogenesis and origin
* Latest data on tuberculosis - the number one infectious disease worldwide
* Recent work on papillomaviruses, herpesviruses, BSE and variant CJD
* Latest data on microbial evasion of immune defences
* Origin and molecular biology of pandemic influenza
* Significance of toxins
* An update on vaccines, prions, immune evasion, microbial ligands and receptors

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Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery. Microbial gene sequencing Up-to-date picture of the global burden of infectious diseases Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence Latest data on combination vaccines, the promise of edible vaccines The spread of antibiotic resistance genes among bacteria HIV1 and HIV2; molecular biology, pathogenesis and origin Latest data on tuberculosis - the number one infectious disease worldwide Recent work on papillomaviruses, herpesviruses, BSE and variant CJD Latest data on microbial evasion of immune defences Origin and molecular biology of pandemic influenza Significance of toxins An update on vaccines, prions, immune evasion, microbial ligands and receptors

Inhalt

Front Cover 1
Mims' Pathogenesis of Infectious Disease Fifth Edition 4
Copyright Page 5
Contents 12
Preface to the Fifth Edition 6
Preface to the Fourth Edition 7
Preface to the Third Edition 8
Preface to the Second Edition 9
Preface to the First Edition 10
Chapter 1. General Principles 16
References 23
Chapter 2. Attachment to and Entry of Microorganisms into the Body 25
Introduction 25
Adhesion/entry: some general considerations 27
The skin 34
Respiratory tract 36
Gastro-intestinal tract 40
Oropharynx 54
Urinogenital tract 58
Conjunctiva 60
The normal microbial flora 62
Exit of microorganisms from the body 67
References 78
Chapter 3. Events Occurring Immediately After the Entry of the Microorganism 82
Growth in epithelial cells 82
Intracellular microorganisms and spread through the body 86
Subepithelial invasion 88
Nutritional requirements of invading microbes 95
References 97
Chapter 4. The Encounter with the Phagocytic Cell and the Microbe's Answers 99
Cell biology of phagocytosis 100
Phagocytosis in polymorphonuclear leucocytes 102
Phagocytosis in macrophages 109
Microbial strategy in relation to phagocytes 112
Growth in the phagocytic cell 124
Killing the phagocyte 126
Entry into the host cell other than by phagocytosis 128
Consequences of defects in the phagocytic cell 130
Summary 131
References 132
Chapter 5. The Spread of Microbes through the Body 134
Direct spread 134
Microbial factors promoting spread 136
Spread via lymphatics 136
Spread via the blood 139
Spread via other pathways 159
References 162
Chapter 6. The Immune Response to Infection 164
Antibody response 171
T-cell-mediated immune response 182
Natural killer cells 186
Macrophages, polymorphs and mast cells 188
Complement and related defence molecules 191
Conclusions concerning the immune response to microorganisms 194
References 196
Chapter 7. Microbial Strategies in Relation to the Immune Response 198
Infection completed before the adaptive immune response intervenes 199
Induction of immunological tolerance 199
Immunosuppression 205
Absence of a suitable target for the immune response 209
Microbial presence in bodily sites inaccessible to the immune response 211
Induction of inappropriate antibody and T-cell responses 212
Antibodies mopped up by soluble microbial antigens 215
Local interference with immune forces 216
Reduced interferon induction or responsiveness 220
Antigenic variation 171
Microorganisms that avoid induction of an immune response 226
References 229
Chapter 8. Mechanisms of Cell and Tissue Damage 231
Infection with no cell or tissue damage 238
Direct damage by microorganisms 239
Microbial toxins 242
Indirect damage via inflammation 290
Indirect damage via the immune response (immunopathology) 292
Other indirect mechanisms of damage 306
Diarrhoea 309
References 318
Chapter 9. Recovery from Infection 322
Immunological factors in recovery 322
Inflammation 336
Complement 338
Interferons 339
Multimechanistic recovery: an example 342
Temperature 344
Tissue repair 346
Resistance to re-infection 349
References 352
Chapter 10. Failure to Eliminate Microbe 354
Latency 357
Persistent infection with shedding 364
Epidemiological significance of persistent infection with shedding 368
Persistent infection without shedding 364
Significance for the individual of persistent infections 372
Conclusions 374
References 374
Chapter 11. Host and Microbial Factors Influencing Susceptibility 376
Genetic factors in the microorganism 377
Genetic factors in the host 382
Hormonal factors and stress 395
Other factors 400
References 404
Chapter 12. Vaccines and How they Work 407
Introduction 407
General principles 409
Complications and side effects of vaccines 421
The development of new vaccines 424
References 429
Appendix 431
Conclusions 439
References 441
Glossary 442
Index 453

Produkt-Details

• Erscheint lt. Verlag: 25.9.2000
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• ISBN-10: 0-08-053850-9 / 0080538509
• ISBN-13: 978-0-08-053850-1 / 9780080538501