International Review of Cell and Molecular Biology (eBook)

Kwang W. Jeon (Herausgeber)

eBook Download: PDF | EPUB

2011 | 1. Auflage
280 Seiten
Elsevier Science (Verlag)
978-0-12-386042-2 (ISBN)

Infos

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2009: 6.088.

* Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional scientists

Inhalt

Front Cover 1
International Review of Cell and Molecular Biology 4
Copyright 5
Contents 6
Contributors 10
Chapter 1: The Membrane Receptor for Plasma Retinol-Binding Protein, A New Type of Cell-Surface Receptor 12
1. Introduction 14
2. Diverse Physiological Functions of Vitamin A, a Molecule Essential for Vertebrate Survival 15
3. Retinol-Binding Protein, the Specific Carrier of Vitamin A in Blood 18
4. Diverse Evidence for the Existence of an RBP Receptor that Mediates Vitamin A Uptake 20
5. Identification of RBP Receptor 23
6. Structure and Function Analysis of the RBP Receptor's Interaction with RBP 31
7. Pertinent Questions Related to RBP Receptor 34
8. RBP Receptor as a Potential Target in Treating Human Diseases 40
9. Concluding Remarks 43
Acknowledgments 43
References 43
Chapter 2: Vascular Smooth-Muscle-Cell Activation... 54
1. Introduction 55
2. Characteristics of Vascular Smooth-Muscle Cells 56
3. Proteomics Approaches for VSMC Proteome Mapping 69
4. Posttranslational Modifications and Their Biological Functions in VSMCs 80
5. From Putative Markers to New Therapeutic Targets 89
6. Concluding Remarks 97
Acknowledgments 98
References 98
Chapter 3: Molecular Basis for Endothelial Lumen Formation and Tubulogenesis During Vasculogenesis and Angiogenic Sprouting 112
1. Introduction 114
2. Overview of Endothelial Lumen Formation and Tubulogenesis 117
3. Molecular Mechanisms Controlling Vascular Lumen Formation 130
4. Functional Roles of Cdc42 and Rac1 in EC Lumen and Tube Formation 139
5. Roles of MT1-MMP and Vascular Guidance Tunnels in EC Lumen Formation and Tube Remodeling Events 147
6. Mechanisms Controlling EC Lumen and Tube Stability 155
7. Role for MMPs in the Molecular Control of Vascular Tube Regression Responses 162
8. Conclusions and Future Directions 164
Acknowledgments 165
References 165
Chapter 4: SUMO and Its Role in Human Diseases 178
1. Introduction 179
2. The Sumoylation Cycle 179
3. Sumoylation and Cancer 181
4. Sumoylation of Proteins Involved in Neurodegenerative Diseases 182
5. Sumoylation and Heart Disease 188
6. Concluding Remarks 189
Acknowledgments 190
References 190
Chapter 5: Focal Adhesion Kinase... 196
1. Introduction 197
2. Biological and Physiological Significance of FAK 198
3. Domain Structure 202
4. Autoinhibition 210
5. FAK Binding Partners 215
6. Development of FAK Therapeutics 223
7. Future Directions 226
References 227
Chapter 6: Roles of Small Ubiquitin-Related Modifiers in Male Reproductive Function 238
1. Introduction 239
2. Regulation of Protein Functions by Sumoylation: Lessons from Other Cell Types 241
3. Unique Aspects of Sumoylation in Male Germ Cells 247
4. Concluding Remarks and Future Perspectives 262
Acknowledgments 263
References 263
Index 272

Produkt-Details

• Erscheint lt. Verlag: 6.4.2011
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik
• ISBN-10: 0-12-386042-3 / 0123860423
• ISBN-13: 978-0-12-386042-2 / 9780123860422