Advances in Molecular Toxicology (eBook)

eBook Download: PDF

2008 | 1. Auflage
275 Seiten
Elsevier Science (Verlag)
978-0-08-056101-1 (ISBN)

Infos

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.
Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed

* Cutting edge reviews by leading workers in the discipline.
* In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines.
* Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.

Inhalt

Cover 1
TOC$Contents 6
Contributors 8
Editor’s Preface 10
CH$Chapter 1. Genotoxicity of Chromate 12
1. Introduction 12
2. Chromate Uptake, Metabolism and Speciation 13
3. Mechanisms of Chromate Genotoxicity 16
Acknowledgements 29
References 29
CH$Chapter 2. Drug-Induced Hepatotoxicity: Learning from Recent Cases of Drug Attrition 36
1. Introduction 36
2. Postulated Mechanisms of Hepatotoxicity 40
3. Proactive Approaches to Drug Safety 58
4. Summary and Conclusions 60
References 63
CH$Chapter 3. Glucuronidation-Dependent Toxicity and Bioactivation 68
1. Introduction 68
2. Pharmacologically Active Glucuronide Conjugates 70
3. Chemically Reactive Glucuronide Conjugates 71
4. Glucuronidation-Dependent Protein Damage 75
5. Glucuronidation-Dependent DNA Damage 79
6. Glucuronidation-Dependent Translocation of Toxins and Carcinogens 81
7. Summary 88
References 88
CH$Chapter 4. Allergic Contact Dermatitis — A Common Skin Disease Caused by Allergic Reactions to Chemicals in Our Environment 98
1. Introduction 99
2. Hand Eczema 100
3. Mechanisms of Contact Allergy 101
4. Hapten–Protein Interactions 106
5. Activation of Prohaptens 112
6. Chemical Aspects on the Most Common Allergens in the Standard Series 119
7. Predictive Testing 120
8. Outlook 123
Acknowledgement 123
References 124
CH$Chapter 5. Inorganic Molecular Toxicology and Chelation Therapy of Heavy Metals and Metalloids 134
1. Introduction 135
2. In Situ Probes of Molecular Form 135
3. Chemical Form and Function in Toxicology 139
4. Molecular Mimicry — A Case of Mistaken Identity 142
5. Synergism and Antagonism 147
6. Chelation Therapy — Towards a Rational Design of Custom Chelators 151
7. Conclusions and Future Directions 158
Acknowledgements 159
References 159
CH$Chapter 6. Pyrimidine Damage and Repair 164
1. Biologically Important Pyrimidines 165
2. Physical Properties of the Pyrimidines 166
3. Hydrolytic Damage 168
4. Oxidation Damage of Pyrimidines 171
5. Alkylation Damage of Pyrimidines 177
6. Repair of Damaged Pyrimidines in DNA 181
7. Conclusions 184
References 184
CH$Chapter 7. Formation, Persistence and Significance of DNA Adduct Formation in Relation to Some Pollutants from a Broad Perspective 194
1. Introduction 195
2. Steps of the Carcinogenic Process 195
3. Biotransformation and Genetic Alteration (DNA Adduct Formation) 204
4. Time-Course Formation and Persistence of DNA Adduct — Is DNA Adduct Predictive of Cancer? 229
5. Conclusion 236
Acknowledgements 238
References 238
IDX$Subject Index 252

Produkt-Details

• Erscheint lt. Verlag: 10.3.2008
• Mitarbeit: Herausgeber (Serie): James C. Fishbein
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik ► Medizintechnik
• ISBN-10: 0-08-056101-2 / 0080561012
• ISBN-13: 978-0-08-056101-1 / 9780080561011