Molecular Genetics, Gene Transfer, and Therapy (eBook)

W. Jean Dodds, James E. Womack (Herausgeber)

eBook Download: PDF

1997 | 1. Auflage
227 Seiten
Elsevier Science (Verlag)
978-0-08-052682-9 (ISBN)

Infos

Animal science is being transformed by advances in molecular genetics. This book covers this exciting transformation. Both the diagnosis and treatment of disease are discussed in seven chapters by a team of leading international authorities. From oncogenesis and hemophilia to retroviral virulence and genome mapping, this volume yields an understanding of fundamental mechanisms of action and insightful means of diagnosis and treatment. Practicing veterinarians and researchers in animal science will find this book useful.

Inhalt

Cover 1
Contents 6
Contributors 10
Preface 12
Chapter I. From Molecular Genetics to Diagnosis and Gene Therapy 16
I. Introduction to Molecular Genetics 17
II. Gene Manipulation 22
III. Studies of Metabolic and Gene Regulation 33
IV. Diagnosis of Genetic Disease 36
V. Therapy of Genetic Diseases 48
VI. Use of Recombinant DNA Methods to Improve Domestic Animals 50
VII. Legal and Ethical Aspects of Patenting Biotechnology 54
References 56
Chapter II. Genes Involved in Oncogenesis 66
I. Introduction 67
II. Detection of Genes Involved in Oncogenesis 68
III. Mapping and Cloning Genes Involved in Oncogenesis 81
IV. Animal Model Systems Used to Study Gene Function 84
V. Identity and Function of Genes Involved in Oncogenesis 88
VI. Applications of Oncogene Research 101
VII. Conclusion 108
References 108
Chapter III. Diagnostic Molecular Genetics 118
I. Introduction 118
II. Methods 119
III. Linkage Analysis 122
IV. Single-Gene Disorders 125
V. Future Directions 129
Acknowledgments 130
References 130
Chapter IV. Gene Therapy for the Hemophilias 134
I. Introduction 134
II. Advantages of Gene Therapy as a Treatment for Hemophilia 135
III. Advantages of Hemophilia as a Model for Gene Therapy 136
IV. Choice of Vector 137
V. Factor IX 141
VI. Factor VIII 144
VII. Summary 145
References 146
Chapter V. Genes Controlling Retroviral Virulence 150
I. Introduction 150
II. Retrovirus Structure and Replication 151
III. Additional Retrovirus Genes 155
IV. Feline Acquired Immunodeficiency Syndrome 159
V. Murine AIDS 160
VI. Simian AIDS 160
VII. Murine Leukemia Virus 161
VIII. Endogenous Retroviruses 163
IX. Lentiviruses 164
References 167
Chapter VI. Mapping Animal Genomes 172
I. Introduction 172
II. Why Map Farm Animal Genomes 173
III. Methods for Animal Genome Mapping 176
IV. Current Status of Animal Genome Maps 183
V. Future Directions 198
References 199
Chapter VII. The Canine Genome 206
I. Introduction 206
II. Applications of a Canine Genetic Map 208
III. Organization of the Canine Genome 211
IV. Development of a Canine Genetic Map 213
V. Targeted Cloning of Canine Genes 223
VI. Considerations and Conclusions 225
References 227
Index 232

Produkt-Details

• Erscheint lt. Verlag: 1.10.1997
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Themenwelt: Veterinärmedizin
• Themenwelt: Weitere Fachgebiete ► Land- / Forstwirtschaft / Fischerei
• ISBN-10: 0-08-052682-9 / 0080526829
• ISBN-13: 978-0-08-052682-9 / 9780080526829