Nanoparticles in Biomedical Imaging (eBook)

Emerging Technologies and Applications

Jeff W.M. Bulte, Michel Modo (Herausgeber)

eBook Download: PDF

2007 | 2008
XVIII, 524 Seiten
Springer New York (Verlag)
978-0-387-72027-2 (ISBN)

Infos

About the Series: Fundamental Biomedical Technologies features titles in multidisciplinary, technology-driven areas, providing the foundations for breakthrough advances in medicine and biology. The term technology refers, in a vigorously unrestrictive sense, to a broad array of engineering disciplines, the sciences of computation and informatics, mathematical models exploiting and advancing methods of mathematical physics, and the development of novel, experimental discovery devices. Titles in this series are designed and selected to provide high-level visionary input for specialists, while presenting overviews of emerging fields for those in related areas. Volumes in this series aim to provide technologists with the material to gain competent entry into biomedical research and biomedical researchers to understand and embrace novel technological foundations and tools. About the Series Editor: Mauro Ferrari is a professor in the Brown Institute of Molecular Medicine, a professor of internal medicine in the division of cardiology, and the chairman of the department of biomedical engineering at the University of Texas Health Science Center in Houston, Texas. He holds concurrent professor appointments at the M.D. Anderson Cancer Center as professor of experimental therapeutics, and at Rice University in bioengineering. Dr. Ferrari is the current President of the Alliance for NanoHealth and he has spearheaded the development of the National Cancer Institute s nanotechnology programs. Dr. Ferrari is also the founder and Editor-in-Chief of Springer s archival journal Biomedical Microdevices. Nanoparticles in Biomedical Imaging Jeff W.M. Bulte and Michel M.J.J. Modo, Editors Nanoparticles in Biomedical Imaging focuses on the use of nanoparticles as chemically engineered small entities that now have emerged as widely used diagnostic agents in biomedicine. The book is logically organized by the specific imaging modalities that are currently central in pre-clinical research and clinical routine, including magnetic resonance imaging, radionuclear imaging, ultrasound imaging, computed tomography, and optical imaging. This comprehensive title provides an expert opinion on the latest developments in biomedical imaging using nanoparticles. Key topics: Use of superparamagnetic iron oxide nanoparticles in magnetic resonance imaging Radiolabeled liposomes and their applications in nuclear medicine Ultrasound bubbles as acoustically reflective medium Exploiting iodinated nanoparticles with computed tomography Quantum dots: the bright future of semiconducting optical agents Nanoparticles in Biomedical Imaging will serve as a useful and valuable resource on the fundamental science of diagnostic nanoparticles in their interactions with biological targets, providing a platform technology for clinical implementation and improved detection of disease. About the Editors: Jeff W.M. Bulte is currently a Professor of Radiology and a Professor of Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine in Baltimore, USA. He serves as the Director of Cellular Imaging in the JHU Institute for Cell Engineering. Michel M.J.J. Modo is the Wolfson Lecturer in Stem Cell Imaging at the Centre for the Cellular Basis of Behaviour and the MRC Centre for Neurodegeneration Research at the Institute of Psychiatry, King s College London.

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The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.

Inhalt

Contents 6
Preface 9
List of Contributors 10
Introduction: The Emergence of Nanoparticles as Imaging Platform in Biomedicine 17
(Para)magnetic Nanoparticles: Applications in Magnetic Resonance Imaging 22
MR Lymphangiography Using Nano- Sized Paramagnetic Contrast Agents with Dendrimer Cores 23
Use of USPIOs for Clinical Lymph Node Imaging 38
Use of SPIOs for Clinical Liver Imaging 54
The Emerging Role of USPIOs for MR Imaging of Atherosclerosis 75
(Super)paramagnetic Nanoparticles: Applications in Noninvasive MR Imaging of Stem Cell Transfer 103
Micron-Sized Iron Oxide Particles ( MPIOs) for Cellular Imaging: More Bang for the Buck 153
Molecular MR Imaging with Paramagnetic Perfluorocarbon Nanoparticles 174
Magnetic Nanosensors for Probing Molecular Interactions 194
Magnetoptical Probes 209
Radiolabeled Nanoparticles: Applications in Nuclear Medicine 218
Use of Radiolabeled Liposomes for Tumor Imaging 219
Use of Radiolabeled Liposomes for Imaging of Infection and Inflammation 245
Sulphur Colloid for Imaging Lymph Nodes and Bone Marrow 260
Acoustically Reflective Nanoparticles: Application in Ultrasound Imaging 293
Use of Ultrasound Bubbles in Lymph Node Imaging 294
Use of Ultrasound Microbubbles for Vascular Imaging 316
Targeted Microbubbles: Ultrasound Contrast Agents for Molecular Imaging 331
Use of Acoustically Active Contrast Agents in Imaging of Inflammation and Atherosclerosis 346
Iodinated Nanoparticles: Applications in Computed Tomography 372
Iodinated Liposomes as Contrast Agents 373
Quantum Dots: Applications in Optical Imaging 413
Quantum Dots and Targeted Nanoparticle Probes for In Vivo Tumor Imaging 414
Investigating the Dynamics of Cellular Processes at the Single Molecule Level with Semiconductor Quantum Dots 427
Targeting Vascular Epitopes Using Quantum Dots 442
Quantum Dots for Cancer Imaging 461
Bimodal Liposomes and Paramagnetic QD- Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis 484
Index 510

Produkt-Details

• Erscheint lt. Verlag: 22.11.2007
• Reihe/Serie: Fundamental Biomedical Technologies
• Reihe/Serie: Fundamental Biomedical Technologies
• Zusatzinfo: XVIII, 524 p. 168 illus., 71 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Technik ► Bauwesen
• Themenwelt: Technik ► Medizintechnik
• Schlagworte: Biomedical Imaging • biomedicine • Bone • Computed tomography (CT) • Dynamics • Tumor • Ultrasound
• ISBN-10: 0-387-72027-8 / 0387720278
• ISBN-13: 978-0-387-72027-2 / 9780387720272