Applying Genomic and Proteomic Microarray Technology in Drug Discovery
Crc Press Inc (Verlag)
978-1-4398-5563-8 (ISBN)
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Updated and revised to reflect recent progress in the field, the second edition discusses:
Expanded omics-driven applications, including the areas of metabolomics and chemical biology
The commercialization of the microarray platform, with a historical perspective aimed at recognizing key technological developments
Solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays
Different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented
The development of the gene expression microarray and representative applications
The development of protein microarray technology, including its history and key applications
Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons.
Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.
Robert S. Matson is president and co-founder of QuantiScientifics, LLC. The company is involved in the commercialization of multiplexed assays for life science, clinical research, and in vitro diagnostics. Previously, Matson was involved in the research and development of microarray technologies, detection chemistries, as well as point-of-care devices for more than 17 years while at Beckman Coulter, Inc. He participated in the National Institute of Standards and Technology’s (NIST) Advanced Technology Program sponsored Genosensor Consortium and collaborated with Sir Edwin Southern on the development of an in situ oligonucleotide array synthesis platform for the corporation. Other work included development of the A2 MicroArray System, a microplate-based array platform for multiplexed micro-ELISA, which QuantiScientifics recently licensed for commercialization.
Omics and Microarrays Revisited. Commercial Microarrays. Supports and Surface Chemistries. Arraying Processes. Gene Expression: Microarray-Based Applications. Protein Microarray Applications. Multiplex Assays. Index.
| Zusatzinfo | 14 Tables, black and white; 200 Illustrations, black and white |
|---|---|
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 566 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pflege | |
| Technik | |
| ISBN-10 | 1-4398-5563-3 / 1439855633 |
| ISBN-13 | 978-1-4398-5563-8 / 9781439855638 |
| Zustand | Neuware |
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