Chirality in Biological Nanospaces
Crc Press Inc (Verlag)
978-1-4398-4002-3 (ISBN)
Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency
The conserved features of the organization of the active site structures of enzymes
The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions
Interactions between the active site residues and the substrate molecules
Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.
Nilashis Nandi was born in Cooch Behar, West Bengal, India (1965). He received his B.Sc. (Hons.) (1983) and M.Sc. (1985) degrees from North Bengal University and Ph.D. (1992) from Visva Bharati University. He became a postdoctoral fellow at the Indian Institute of Science, India (1993–1997), a J.S.P.S. postdoctoral fellow at Nagoya University, Japan (1997–1999), and an Alexander von Humboldt postdoctoral fellow at the Max Planck Institute of Colloids and Interfaces, Germany (1999–2000). Dr. Nandi was a faculty member in the chemistry group of Birla Institute of Technology and Science, Pilani, India from 2001–2007 and became a professor in the Department of Chemistry, University of Kalyani in 2008 where he has worked ever since. His research interest is focused on theoretical and computational studies in biophysical chemistry.
Introduction. Chiral discrimination in the active site of oxidoreductase. Transferases and chiral discrimination. Influence of chirality on the hydrolysis reactions within the active site of hydrolases. Influence of chirality on the reactions in the active site of lyases. Chiral discrimination in the active site of ligases. Summary and future.
| Zusatzinfo | 19 Illustrations, color; 76 Illustrations, black and white |
|---|---|
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 453 g |
| Themenwelt | Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik) |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik | |
| Technik ► Umwelttechnik / Biotechnologie | |
| ISBN-10 | 1-4398-4002-4 / 1439840024 |
| ISBN-13 | 978-1-4398-4002-3 / 9781439840023 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
