Enantiomer Separation

Fundamentals and Practical Methods

Buch | Softcover

333 Seiten

2010 | Softcover reprint of hardcover 1st ed. 2004
Springer (Verlag)
978-90-481-6640-4 (ISBN)

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In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.

Optical resolutions by inclusion complexation with a chiral host compound.- Crystalline dipeptides: their molecular recognition to be useful to enantiomer separation.- Optical resolution via complex formation with O,O'-dibenzoyltataric acid.- Spontaneous chiral crystallization of achiral materials and absolute asymmetric transformation in the chiral crystalline environment.- Preferential enrichment: a dynamic enantiomeric resolution phenomenon caused by polymorphic transition during crystallization.- Optical resolution by means of crystallization.- Lipase-catalyzed kinetic resolution of racemates: a versatile method for the separation of enantiomers.- Enzymatic kinetic resolution.- Preparative-scale separation of enantiomers on chiral stationary phases by gas chromatography.- Practical resolution of enantiomers by high-performance liquid chromatography.

Erscheint lt. Verlag	1.12.2010
Zusatzinfo	VII, 333 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	160 x 240 mm
Themenwelt	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Naturwissenschaften ► Chemie ► Organische Chemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
	Technik
ISBN-10	90-481-6640-3 / 9048166403
ISBN-13	978-90-481-6640-4 / 9789048166404
Zustand	Neuware